Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
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DOI：
10.1038/ng.287
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发表时间：
2009-01
期刊：
影响因子：
30.8
通讯作者：
Hirschhorn, Joel N.
中科院分区：
文献类型：
--
作者：
Willer, Cristen J.;Speliotes, Elizabeth K.;Loos, Ruth J. F.;Li, Shengxu;Lindgren, Cecilia M.;Heid, Iris M.;Berndt, Sonja I.;Elliott, Amanda L.;Jackson, Anne U.;Lamina, Claudia;Lettre, Guillaume;Lim, Noha;Lyon, Helen N.;McCarroll, Steven A.;Papadakis, Konstantinos;Qi, Lu;Randall, Joshua C.;Roccasecca, Rosa Maria;Sanna, Serena;Scheet, Paul;Weedon, Michael N.;Wheeler, Eleanor;Zhao, Jing Hua;Jacobs, Leonie C.;Prokopenko, Inga;Soranzo, Nicole;Tanaka, Toshiko;Timpson, Nicholas J.;Almgren, Peter;Bennett, Amanda;Bergman, Richard N.;Bingham, Sheila A.;Bonnycastle, Lori L.;Brown, Morris;Burtt, Noel L. P.;Chines, Peter;Coin, Lachlan;Collins, Francis S.;Connell, John M.;Cooper, Cyrus;Smith, George Davey;Dennison, Elaine M.;Deodhar, Parimal;Elliott, Paul;Erdos, Michael R.;Estrada, Karol;Evans, David M.;Gianniny, Lauren;Gieger, Christian;Gillson, Christopher J.;Guiducci, Candace;Hackett, Rachel;Hadley, David;Hall, Alistair S.;Havulinna, Aki S.;Hebebrand, Johannes;Hofman, Albert;Isomaa, Bo;Jacobs, Kevin B.;Johnson, Toby;Jousilahti, Pekka;Jovanovic, Zorica;Khaw, Kay-Tee;Kraft, Peter;Kuokkanen, Mikko;Kuusisto, Johanna;Laitinen, Jaana;Lakatta, Edward G.;Luan, Jian'an;Luben, Robert N.;Mangino, Massimo;McArdle, Wendy L.;Meitinger, Thomas;Mulas, Antonella;Munroe, Patricia B.;Narisu, Narisu;Ness, Andrew R.;Northstone, Kate;O'Rahilly, Stephen;Purmann, Carolin;Rees, Matthew G.;Ridderstrale, Martin;Ring, Susan M.;Rivadeneira, Fernando;Ruokonen, Aimo;Sandhu, Manjinder S.;Saramies, Jouko;Scott, Laura J.;Scuteri, Angelo;Silander, Kaisa;Sims, Matthew A.;Song, Kijoung;Stephens, Jonathan;Stevens, Suzanne;Stringham, Heather M.;Tung, Y. C. Loraine;Valle, Timo T.;Van Duijn, Cornelia M.;Vimaleswaran, Karani S.;Vollenweider, Peter;Waeber, Gerard;Wallace, Chris;Watanabe, Richard M.;Waterworth, Dawn M.;Watkins, Nicholas;Witteman, Jacqueline C. M.;Zeggini, Eleftheria;Zhai, Guangju;Zillikens, M. Carola;Altshuler, David;Caulfield, Mark J.;Chanock, Stephen J.;Farooqi, I. Sadaf;Ferrucci, Luigi;Guralnik, Jack M.;Hattersley, Andrew T.;Hu, Frank B.;Jarvelin, Marjo-Riitta;Laakso, Markku;Mooser, Vincent;Ong, Ken K.;Ouwehand, Willem H.;Salomaa, Veikko;Samani, Nilesh J.;Spector, Timothy D.;Tuomi, Tiinamaija;Tuomilehto, Jaakko;Uda, Manuela;Uitterlinden, Andre G.;Wareham, Nicholas J.;Deloukas, Panagiotis;Frayling, Timothy M.;Groop, Leif C.;Hayes, Richard B.;Hunter, David J.;Mohlke, Karen L.;Peltonen, Leena;Schlessinger, David;Strachan, David P.;Wichmann, H-Erich;McCarthy, Mark I.;Boehnke, Michael;Barroso, Ines;Abecasis, Goncalo R.;Hirschhorn, Joel N.
只有两个基因座FTO和MC4R的常见变异与人类的体重指数（BMI）可重复相关。为了确定其他基因座，我们对15项BMI全基因组关联研究（n > 32，000）进行了荟萃分析，并对14个其他队列（n > 59，000）中的主要信号进行了随访。我们强有力地证实了FTO和MC4R，并确定了6个额外的基因座（P < 5 × 10−8）：TMEM 18，KCTD 15，GNPDA 2，SH 2B1，MTCH 2和NEGR 1（其中45 kb缺失多态性是一个候选的因果变异）。几个可能的致病基因在中枢神经系统（CNS）中高度表达或已知在CNS中起作用，强调了CNS在肥胖易感性中的作用，如在罕见的单基因形式的肥胖中。
Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 × 10−8): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
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影响因子：
14.9
作者：
Cartegni, L;Wang, JH;Krainer, AR
通讯作者：
Krainer, AR
影响因子：
7.7
作者：
Freathy RM;Timpson NJ;Lawlor DA;Pouta A;Ben-Shlomo Y;Ruokonen A;Ebrahim S;Shields B;Zeggini E;Weedon MN;Lindgren CM;Lango H;Melzer D;Ferrucci L;Paolisso G;Neville MJ;Karpe F;Palmer CN;Morris AD;Elliott P;Jarvelin MR;Smith GD;McCarthy MI;Hattersley AT;Frayling TM
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影响因子：
30.8
作者：
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通讯作者：
Kooner, Jaspal S.
影响因子：
9.8
作者：
Edenberg, HJ;Dick, DM;Begleiter, H
通讯作者：
Begleiter, H
影响因子：
3.5
作者：
Liu, Yong-Jun;Liu, Xiao-Gang;Deng, Hong-Wen
通讯作者：
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