Association of leg-length inequality with knee osteoarthritis: a cohort study.
Association of leg-length inequality with knee osteoarthritis: a cohort study.
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DOI：
10.7326/0003-4819-152-5-201003020-00006
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发表时间：
2010-03-02
影响因子：
39.2
通讯作者：
Felson DT
中科院分区：
文献类型：
--
作者：
Harvey WF;Yang M;Cooke TD;Segal NA;Lane N;Lewis CE;Felson DT
腿长不均在普通人群中很常见，可能会加速膝骨性关节炎的发展。为了确定腿长不均是否与普遍的、发生的和进行性的膝骨性关节炎有关，前瞻性观察性队列研究。受试者从伯明翰、阿勒颇和爱荷华市的社区招募，IA 3026名受试者，年龄50-79岁，患有或处于膝骨性关节炎的高危状态。暴露是从四肢X光片测量的腿长不均。结果是普遍的、偶发的和进行性的膝骨性关节炎。放射学骨关节炎定义为凯尔格伦和劳伦斯≥2级，症状性骨关节炎定义为持续疼痛的膝关节的放射学疾病。腿长不等≥1 cm与短肢骨性关节炎相关(53%vs.36%，OR1.9，95%CI1.5~2.4)和症状性(30%vs.17%，OR2.0，95%CI1.6~2.6)。在短肢(15%比9%，OR 1.7，95%CI1.2-2.4)和较长肢体(13%比9%，OR 1.5，95%CI1.0-2.1)中，≥1 cm不等长与出现症状性骨关节炎有关。≥不等长1厘米与短肢进行性骨关节炎的风险增加(29%比24%，OR 1.3，95%CI 1.0-1.7)相关。随访的时间可能不够长，不足以充分识别发病和进展的病例。腿长的测量，包括射线照片，有测量误差，这可能导致错误的分类。放射学上的腿长不均与普遍的、偶发的症状性和进行性膝骨性关节炎有关。这些结果表明，腿长不等是膝骨性关节炎的一个潜在的可修改的危险因素。国家老龄问题研究所
Leg length inequality is common in the general population and may accelerate development of knee osteoarthritis. To determine if leg length inequality is associated with prevalent, incident and progressive knee osteoarthritis, Prospective observational cohort study. Subjects recruited from the community in Birmingham, AL and Iowa City, IA 3026 subjects, age 50-79, with or at high risk for knee osteoarthritis. The exposure was leg length inequality measured from full limb radiographs. The outcomes were prevalent, incident, and progressive knee osteoarthritis. Radiographic osteoarthritis was defined as Kellgren and Lawrence grade ≥2 and symptomatic osteoarthritis was defined as radiographic disease in a consistently painful knee. Leg length inequality ≥1 cm was associated with prevalent radiographic (53% vs. 36%, OR 1.9, 95%CI 1.5-2.4) and symptomatic (30% vs. 17%, OR 2.0, 95%CI 1.6-2.6) osteoarthritis in the shorter limb. Inequality ≥1 cm was associated with incident symptomatic osteoarthritis in the shorter (15% vs. 9%, OR 1.7, 95%CI 1.2-2.4) and longer (13% vs. 9%, OR 1.5, 95%CI 1.0-2.1) limb. Inequality ≥1 cm was associated with increased odds (29% vs. 24%, OR 1.3, 95%CI 1.0-1.7) of progressive osteoarthritis in the shorter limb. The duration of follow-up may not be long enough to adequately identify cases of incidence and progression. Measurements of leg length, including radiographic, have measurement error which could result in misclassification. Radiographic leg length inequality was associated with prevalent, incident symptomatic and progressive knee osteoarthritis. These results point to leg length inequality as a potentially modifiable risk factor for knee osteoarthritis. National Institute on Aging
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影响因子：
7
作者：
Golightly, Y. M.;Allen, K. D.;Jordan, J. M.
通讯作者：
Jordan, J. M.
DOI：
10.2106/00004623-199904000-00010
发表时间：
1999-04-01
影响因子：
5.3
作者：
Bhave, A;Paley, D;Herzenberg, JE
通讯作者：
Herzenberg, JE
影响因子：
--
作者：
Felson, David T.;Niu, Jingbo;Aliabadi, Piran
通讯作者：
Aliabadi, Piran
影响因子：
--
作者：
Niu, J.;Zhang, Y. Q.;Torner, J.;Nevitt, M.;Lewis, C. E.;Aliabadi, P.;Sack, B.;Clancy, M.;Sharma, L.;Felson, D. T.
通讯作者：
Felson, D. T.
影响因子：
3
作者：
SOUKKA, A;ALARANTA, H;HELIOVAARA, M
通讯作者：
HELIOVAARA, M