Design and execution of a public randomization ceremony to enhance stakeholder engagement within a cluster randomized trial to improve tuberculosis diagnosis in Uganda.
Design and execution of a public randomization ceremony to enhance stakeholder engagement within a cluster randomized trial to improve tuberculosis diagnosis in Uganda.
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DOI：
10.1016/j.conctc.2021.100707
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发表时间：
2021-06
影响因子：
1.5
通讯作者：
Cattamanchi A
中科院分区：
文献类型：
--
作者：
Reza TF;Nalugwa T;Nantale M;Adams K;Fielding K;Nakaweesa A;Oyuku D;Nabwire S;Musinguzi J;Ojok C;Babirye D;Ackerman SL;Handley MA;Kityamuwesi A;Dowdy DW;Moore DAJ;Davis JL;Turyahabwe S;Katamba A;Cattamanchi A
公开随机化仪式被提议作为一种战略，以加强利益攸关方的参与，并解决与试验随机化相关的关切和误解。然而，很少有公开发表的例子描述如何在利益相关者有意义的参与下进行公开的随机化仪式，或者这种仪式如何影响利益相关者对随机化和随机化过程的看法。在乌干达坎帕拉举行的有70名利益相关者参加的公开随机仪式上，对GeneXpert与结核病治疗挂钩的绩效评估(XPEL-TB)试验进行了整群随机化。乌干达国家结核病和麻风病方案代理助理专员和试验调查员所作的介绍强调了试验如何旨在促进国家结核病目标，以及利益攸关方如何为干预设计作出贡献。使用简单的文本和视觉描述了随机化的目的和过程。随机化是一项互动活动，需要每个试验点的利益相关者参与。在仪式结束时对利益相关者进行的调查表明，他们对随机化的理解程度很高(98%)，对随机化过程的信任度(96%)，对随机化结果的满意度(96%)。应更常规地考虑公开随机化仪式，以使利益攸关方参与并解决对社区试验随机化过程的公平性和公正性的潜在关切。
Public randomization ceremonies have been proposed as a strategy to strengthen stakeholder engagement and address concerns and misconceptions associated with trial randomization. However, there are few published examples that describe how to conduct a public randomization ceremony with meaningful stakeholder engagement or how such ceremonies impact stakeholder perceptions about randomization and the randomization process. Cluster randomization for the GeneXpert Performance Evaluation for Linkage to Tuberculosis Care (XPEL-TB) trial was conducted at a public randomization ceremony attended by 70 stakeholders in Kampala, Uganda. Presentations given by the Acting Assistant Commissioner from the Uganda National Tuberculosis and Leprosy Programme and trial investigators emphasized how the trial aimed to further national TB goals, as well as how stakeholders contributed to the intervention design. The purpose and process of randomization were described using simple text and visuals. Randomization was an interactive activity that required participation of stakeholders from each trial site. A survey administered to stakeholders at the end of the ceremony suggested high comprehension of randomization (98%), trust in the randomization process (96%), and satisfaction with randomization outcomes (96%). Public randomization ceremonies should be considered more routinely to engage stakeholders in and address potential concerns about the fairness and impartiality of the randomization process for community-based trials.
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影响因子：
1.5
作者：
Ruzagira E;Baisley K;Kamali A;Grosskurth H
通讯作者：
Grosskurth H
影响因子：
105.7
作者：
Gill, Christopher J.;Phiri-Mazala, Grace;Hamer, Davidson H.
通讯作者：
Hamer, Davidson H.
影响因子：
16.1
作者：
Cowan, Frances M.;Davey, Calum;Hargreaves, James R.
通讯作者：
Hargreaves, James R.
案例研究：社区参与和临床试验成功：向非裔美国妇女宣传。
DOI：
10.1111/cts.12264
发表时间：
2015-08
期刊：
Clinical and translational science
影响因子：
--
作者：
Johnson DA;Joosten YA;Wilkins CH;Shibao CA
通讯作者：
Shibao CA
影响因子：
7.2
作者：
Reza, Tania F.;Nalugwa, Talemwa;Cattamanchi, Adithya
通讯作者：
Cattamanchi, Adithya