Noise-Induced Hearing Threshold Shift Correlated with Body Weight and External-Ear Amplification in Chinchilla: a Preliminary Analysis.
Noise-Induced Hearing Threshold Shift Correlated with Body Weight and External-Ear Amplification in Chinchilla: a Preliminary Analysis.
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DOI：
10.1007/s10162-023-00913-2
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发表时间：
2023-12
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影响因子：
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外耳放大(EEA)在儿童、青少年和成人参与者的大型数据集中被证明在5-19分贝-A之间变化。然而，可变的EEA是一个被忽视的特征，可能在个体噪声性听力损失(NIHL)易感性中发挥作用。5-19分贝-A的噪声暴露意味着高EEA个体理论上经历的NIHL风险是低EEA个体的3-4倍。这项初步分析的目的是检验这样一种假设，即较高的EEA与较高的噪声诱导的阈值漂移敏感性相关。将9只龙猫暴露于分贝声压级的4 kHz倍频程噪声中24小时，分别于暴露前、暴露后24小时和暴露后4周进行听性脑干反应阈值测试。分析EEA与阈值漂移的关系。开耳EEA为11~19dBSPL，闭耳EEA为10~21dBSPL。更高的闭合耳EEA与更高的NIHL易感性相关(p = 0.04)，以及更低的体重(p = 0.01)。雄性动物比雌性动物表现出更多的阈值漂移(p = 0.02)，体重比雌性动物低(p = 0.02)，而闭塞耳声发射更高(雄性平均 = 18分贝，雌性平均 = 15分贝)。总而言之，在最小的动物中观察到了更高的阈值漂移敏感性，即最高闭塞耳朵EEA的动物，以及雄性动物(往往有更高的闭塞耳朵EEA)。考虑到较小的身体尺寸和较高的闭合耳EEA之间已建立的关系，这些初步结果表明，身体大小(和闭塞耳朵EEA；身体大小的函数)可能是NIHL易感性差异的潜在潜在驱动因素，而不是真正的性别差异。
External-ear amplification (EEA) has been shown to vary from 5–19 dB-A in large datasets of pediatric, adolescent, and adult human participants. However, variable EEA is an overlooked characteristic that likely plays a role in individual noise-induced hearing loss (NIHL) susceptibility. A noise exposure varying 5–19 dB-A translates to high-EEA individuals theoretically experiencing 3–4 times greater NIHL risk than low-EEA individuals. The purpose of this preliminary analysis was to test the hypothesis that higher EEA is correlated with increased noise-induced threshold shift susceptibility. Nine chinchillas were exposed to 4-kHz octave-band noise at 89 dB-SPL for 24 h. Auditory brainstem response thresholds were obtained pre-exposure, 24-h post-exposure, and 4-week post-exposure. Relationships between EEA and threshold shift were analyzed. Open-ear EEA ranged 11–19 dB-SPL, and occluded-ear EEA ranged 10–21 dB-SPL. Higher occluded-ear EEA was correlated with increased NIHL susceptibility (p = 0.04), as was lower body weight (p = 0.01). Male animals exhibited more threshold shift than female animals (p = 0.02), lower body weight than female animals (p = 0.02), and higher occluded-ear EEA (male mean = 18 dB; female mean = 15 dB). Taken together, increased threshold shift susceptibility was observed in the smallest animals, animals with the highest occluded-ear EEA, and in male animals (which tended to have higher occluded-ear EEA). Given the established relationship between smaller body size and higher occluded-ear EEA, these preliminary results suggest that body size (and occluded-ear EEA; a function of body size) could be a potential, underlying driver of NIHL susceptibility differences, rather than true sex differences.
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影响因子：
2.4
作者：
DRESCHER, DG;ELDREDGE, DH
通讯作者：
ELDREDGE, DH
DOI：
10.1007/s10162-010-0242-3
发表时间：
2011-04-01
影响因子：
2.4
作者：
Jones, Heath G.;Koka, Kanthaiah;Tollin, Daniel J.
通讯作者：
Tollin, Daniel J.
影响因子：
2.8
作者：
Koka, Kanthaiah;Jones, Heath G.;Tollin, Daniel J.
通讯作者：
Tollin, Daniel J.
影响因子：
3.7
作者：
GERHARDT, KJ;RODRIGUEZ, GP;MOUL, ML
通讯作者：
MOUL, ML
影响因子：
2.4
作者：
Grinn, Sarah K.;Le Prell, Colleen G.
通讯作者：
Le Prell, Colleen G.