Antimicrobial power of biosynthesized Ag nanoparticles using refined Ginkgo biloba leaf extracts
Antimicrobial power of biosynthesized Ag nanoparticles using refined Ginkgo biloba leaf extracts
复制标题
使用精制银杏叶提取物生物合成银纳米颗粒的抗菌能力
DOI：
10.1007/s11706-022-0594-8
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发表时间：
2022-05
影响因子：
2.7
通讯作者：
Yanfen Wan
中科院分区：
文献类型：
--
作者：
Wenbo Zhuang;Dafeng Hu;Xudong Zhang;Kai Xiong;Xiao Ding;Jian Lu;Yong Mao;Peng Yang;Chao Liu;Yanfen Wan
银纳米粒子（Ag NPs）相对于现有的抗菌剂具有更有效、毒性更小、更经济的优点，在纳米医学应用中显示出巨大的潜力。在这项工作中，我们报告了一种“绿色”的方法，用于快速，有效地合成银纳米粒子使用银杏叶提取物作为还原剂和封端剂。研究了银纳米颗粒对真菌和细菌的特性。结果表明，银杏叶提取物是制备均匀和单分散银纳米粒子的关键。所制备的银纳米粒子具有显著的抗菌活性。银纳米粒子对大肠杆菌和铜绿假单胞菌的最小抑制浓度分别为0.044和0.088 µg·mL−1。此外，银纳米颗粒表现出优异的杀菌性能对MDR-铜绿假单胞菌。结果表明，纳米银对大肠杆菌和金黄色葡萄球菌的抗菌活性与活性氧的积累密切相关。该研究为银纳米粒子的高效绿色合成及其抗菌应用提供了指导。
Silver nanoparticles (Ag NPs), relative to existing antibacterial agents, are more effective, less toxic and more economical, and have shown enormous potential for the nanomedicine application. In this work, we report a ‘green’ method for the rapid and efficient synthesis of Ag NPs using Ginkgo biloba extracts as reducing agent and capping agent. The properties of Ag NPs against fungi and bacteria were investigated. The results showed that the Ginkgo biloba extracts are crucial for the preparation of uniform and monodispersed Ag NPs. The prepared Ag NPs exhibited remarkable antibacterial activities. The minimum inhibitory concentrations of Ag NPs for Escherichia coli and Pseudomonas aeruginosa were 0.044 and 0.088 µg·mL−1, respectively. Moreover, Ag NPs exhibited excellent bactericidal performance against MDR-Pseudomonas aeruginosa. It was found that the effect of the antibacterial activity of Ag NPs on Escherichia coli and Staphylococcus aureus was tightly related to the reactive oxygen species accumulation. This research provides guidelines for the efficient green synthesis of Ag NPs and its antibacterial applications.
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通讯作者：
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作者：
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