Mechanobiology of tumor invasion: engineering meets oncology.
Mechanobiology of tumor invasion: engineering meets oncology.
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DOI：
10.1016/j.critrevonc.2011.11.005
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发表时间：
2012-08
影响因子：
6.2
通讯作者：
Reinhart-King, Cynthia A.
中科院分区：
文献类型：
--
作者：
Carey, Shawn P.;D'Alfonso, Timothy M.;Shin, Sandra J.;Reinhart-King, Cynthia A.
物理科学和工程通过模型系统、工具和指标将新的视角引入癌症研究，这些模型系统、工具和指标能够将基础科学观察与临床数据相结合。这些方法有助于确定在癌症进展期间驱动过程的几种总体机制，包括肿瘤生长、血管生成和转移。在肿瘤细胞侵袭（转移的第一个临床可观察步骤）期间，细胞表现出通常不能由任何单一分子机制定义的多样和进化的物理表型，并且机械生物学已用于研究包括“侵袭表型”的物理细胞行为。在这篇综述中，我们讨论了不断发展的病理学特征和肿瘤侵袭的体外机械生物学特征，重点是新兴的物理生物学和机械生物学策略，这些策略有助于对肿瘤细胞侵袭的更强大的机械理解。这些物理方法最终可能有助于更好地预测和识别肿瘤转移。
The physical sciences and engineering have introduced novel perspectives into the study of cancer through model systems, tools, and metrics that enable integration of basic science observations with clinical data. These methods have contributed to the identification of several overarching mechanisms that drive processes during cancer progression including tumor growth, angiogenesis, and metastasis. During tumor cell invasion – the first clinically observable step of metastasis – cells demonstrate diverse and evolving physical phenotypes that cannot typically be defined by any single molecular mechanism, and mechanobiology has been used to study the physical cell behaviors that comprise the “invasive phenotype”. In this review, we discuss the continually evolving pathological characterization and in vitro mechanobiological characterization of tumor invasion, with emphasis on emerging physical biology and mechanobiology strategies that have contributed to a more robust mechanistic understanding of tumor cell invasion. These physical approaches may ultimately help to better predict and identify tumor metastasis.
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