Size at birth and cord blood levels of insulin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-1 (IGFBP-1), IGFBP-3, and the soluble IGF-II/mannose-6-phosphate receptor in term human infants. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood.
Size at birth and cord blood levels of insulin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-1 (IGFBP-1), IGFBP-3, and the soluble IGF-II/mannose-6-phosphate receptor in term human infants. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood.
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出生时的大小和脐带血中胰岛素、胰岛素样生长因子 I (IGF-I)、IGF-II、IGF 结合蛋白-1 (IGFBP-1)、IGFBP-3 和可溶性 IGF-II/甘露糖的水平
DOI：
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发表时间：
2000
影响因子：
5.8
通讯作者：
D. B. Dunger
中科院分区：
文献类型：
--
作者：
K. Ong;J. Kratzsch;W. Kiess;M. Costello;C. Scott;D. B. Dunger
实验啮齿动物研究表明，胰岛素样生长因子II（IGF-II）促进胎儿生长，而非信号IGF-II受体（IGF 2 R）是抑制性的;在人类中，其影响尚不清楚。IGF 2 R的可溶性循环形式抑制IGF-II介导的DNA合成，因此可能抑制胎儿生长。我们测量了199例正常足月单胎婴儿的脐血IGF-II、可溶性IGF 2 R、胰岛素、IGF-I、IGFBP-1和IGFBP-3水平，并研究了它们与出生时体重、身长、头围、体重指数和胎盘重量的关系。IGF-II水平与IGF-I（r = 0.29; P < 0.0005）、IGFBP-3（r = 0.45; P < 0.0005）和可溶性IGF 2 R（r = 0.20; P < 0.005）水平相关。胰岛素和IGF-I与出生时的所有尺寸参数呈正相关。IGF-II与体重指数（r = 0.18; P < 0.05）和胎盘重量（r = 0.18; P < 0.05）呈弱相关，IGF-II与IGF 2 R的摩尔比与出生体重也呈相关（r = 0.15; P < 0.05）。IGFs和出生时的大小之间的相关性在非经产妊娠中更强;在这些妊娠中，IGF-I（r = 0.52; P < 0.0005），IGFBP-3（r = 0.41; P < 0.0005），IGF-II与IGF 2 R的比值（r = 0.40; P < 0.0005）与胎盘重量的关系最为密切，共解释其变异量的39%。我们首次证明了出生时循环IGF-II和可溶性IGF 2 R水平与大小之间的关系，支持它们在人类胎儿生长中的假定相反作用。
Experimental rodent studies demonstrate that insulin-like growth factor II (IGF-II) promotes fetal growth, whereas the nonsignaling IGF-II receptor (IGF2R) is inhibitory; in humans their influence is as yet unclear. A soluble, circulating form of IGF2R inhibits IGF-II mediated DNA synthesis and may therefore restrain fetal growth. We measured cord blood levels of IGF-II, soluble IGF2R, insulin, IGF-I, IGF-binding protein-1 (IGFBP-1), and IGFBP-3 and examined their relationships to weight, length, head circumference, ponderal index, and placental weight at birth in 199 normal term singletons. IGF-II levels correlated with levels of IGF-I (r = 0.29; P < 0.0005), IGFBP-3 (r = 0.45; P < 0.0005), and soluble IGF2R (r = 0.20; P < 0.005). Insulin and IGF-I were positively related to all parameters of size at birth. IGF-II was weakly related to ponderal index (r = 0.18; P < 0.05) and placental weight (r = 0.18; P < 0.05), and the molar ratio of IGF-II to IGF2R was also related to birth weight (r = 0.15; P < 0.05). Correlations between the IGFs and size at birth were stronger in nonprimiparous pregnancies; in these, IGF-I (r = 0.52; P < 0.0005), IGFBP-3 (r = 0.41; P < 0.0005), and the IGF-II to IGF2R ratio (r = 0.40; P < 0.0005) were most closely related to placental weight, together accounting for 39% of its variance. We demonstrate for the first time relationships between circulating IGF-II and soluble IGF2R levels and size at birth, supporting their putative opposing roles in human fetal growth.
DOI：
10.1210/jcem.80.5.7538146
发表时间：
1995-05
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
L. Giudice;F. de Zegher;S. Gargosky;B. Dsupin;L. de las Fuentes;R. Crystal;R. Hintz;R. Rosenfeld
通讯作者：
L. Giudice;F. de Zegher;S. Gargosky;B. Dsupin;L. de las Fuentes;R. Crystal;R. Hintz;R. Rosenfeld
影响因子：
10.5
作者：
LAU, MMH;STEWART, CEH;STEWART, CL
通讯作者：
STEWART, CL