Age Differences in Striatal Delay Sensitivity during Intertemporal Choice in Healthy Adults.
Age Differences in Striatal Delay Sensitivity during Intertemporal Choice in Healthy Adults.
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DOI：
10.3389/fnins.2011.00126
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发表时间：
2011
影响因子：
4.3
通讯作者：
McClure SM
中科院分区：
文献类型：
--
作者：
Samanez-Larkin GR;Mata R;Radu PT;Ballard IC;Carstensen LL;McClure SM
跨期选择是一类无处不在的决策，涉及在未来不同时间可用的结果之间进行选择。我们调查了支持健康的年轻人和老年人的跨期决策的神经系统。使用功能神经成像，我们发现衰老与大脑对延迟奖励做出反应的区域发生变化有关。尽管我们重复了与中脑边缘多巴胺系统相关的大脑区域对即时奖励的优先反应的发现，但我们发现在老年人的腹侧纹状体中有一个单独的区域，具有非常温和的时间依赖性。在老年人中，纹状体区域的激活对延迟相对不敏感，但在年轻人中则不是。由于多巴胺系统被认为支持随着时间的推移对未来奖励的联想学习，我们观察到的功能转移可能是因为随着年龄的增长，对延迟奖励的更多经验。确定这些决定背后的神经系统的差异，可能有助于建立一个更全面的跨期选择与年龄相关的变化模型。
Intertemporal choices are a ubiquitous class of decisions that involve selecting between outcomes available at different times in the future. We investigated the neural systems supporting intertemporal decisions in healthy younger and older adults. Using functional neuroimaging, we find that aging is associated with a shift in the brain areas that respond to delayed rewards. Although we replicate findings that brain regions associated with the mesolimbic dopamine system respond preferentially to immediate rewards, we find a separate region in the ventral striatum with very modest time dependence in older adults. Activation in this striatal region was relatively insensitive to delay in older but not younger adults. Since the dopamine system is believed to support associative learning about future rewards over time, our observed transfer of function may be due to greater experience with delayed rewards as people age. Identifying differences in the neural systems underlying these decisions may contribute to a more comprehensive model of age-related change in intertemporal choice.
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影响因子：
56.9
作者：
Hare, Todd A.;Camerer, Colin F.;Rangel, Antonio
通讯作者：
Rangel, Antonio
DOI：
10.1073/pnas.1014457108
发表时间：
2011-09-13
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
25
作者：
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通讯作者：
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影响因子：
3.7
作者：
Loeckenhoff, Corinna E.;O'Donoghue, Ted;Dunning, David
通讯作者：
Dunning, David
影响因子：
13.7
作者：
Laibson, D
通讯作者：
Laibson, D