The expression and clinical significance of programmed cell death receptor 1 and its ligand in tumor tissues of patients with extranodal nasal NK/T cell lymphoma.
The expression and clinical significance of programmed cell death receptor 1 and its ligand in tumor tissues of patients with extranodal nasal NK/T cell lymphoma.
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DOI：
10.1038/s41598-021-02515-5
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发表时间：
2022-01-07
影响因子：
4.6
通讯作者：
Xu C
中科院分区：
文献类型：
--
作者：
Feng Y;Feng X;Jing C;Yu X;Zheng Y;Xu C
适当的生物标志物可能有助于区分不同类型淋巴瘤的生物学行为及其对传统化疗的反应。结外自然杀伤/T细胞淋巴瘤（ENKTL）和弥漫性大B细胞淋巴瘤（DLBCL）属于非霍奇金淋巴瘤的不同亚型，其生物学行为和预后有很大差异，程序性细胞死亡受体1（PD-1）及其配体（PD-L1）在这两类疾病中的作用已被研究。然而，针对ENKTL与DLBCL之间PD-1/PD-L1水平差异的研究较少，为探讨二者的差异及相关临床应用价值，收集了24例新诊断的ENKTL患者和42例新诊断的弥漫性大B细胞淋巴瘤（DLBCL）患者的临床资料和肿瘤组织石蜡切片。免疫组化法检测肿瘤组织中PD-1/PD-L1的表达。分析ENKTL患者PD-1/PD-L1水平与临床资料的关系。两组患者中ENKTL患者肿瘤组织中PD-1水平显著低于DLBCL患者（P < 0.05），而ENKTL患者肿瘤组织中PD-L1水平与DLBCL患者无差异（P> 0.05）。此外，具有B症状、乳酸脱氢酶（LDH）水平升高和血红蛋白（HGB）浓度降低的ENKTL患者肿瘤组织中PD-1水平较低。肿瘤组织PD-L1水平、LDH水平、EB病毒基因组（EBV-DNA）拷贝数和Ki-67指数可能影响ENKTL患者的预后（P < 0.05），但不是独立因素。肿瘤组织中PD-L1水平在ENKTL患者中具有临床意义，提示PD-1/PD-L1信号通路可能参与ENKTL的免疫逃逸，并在不同的淋巴瘤亚型中发挥不同的作用。
Appropriate biomarkers may help distinguish the biological behavior of different types of lymphoma and their response to traditional chemotherapy. Extranodal natural killer/T-cell lymphoma (ENKTL) and diffuse large B-cell lymphoma (DLBCL) belong to different subtypes of non-Hodgkin's lymphoma, the biological behavior and prognosis of them are very different, programmed cell death receptor 1 (PD-1) and its ligand (PD-L1) have been investigated in these two types of diseases. However, few studies addressed the difference of PD-1/PD-L1 levels between ENKTL and DLBCL, in order to find out the difference and related clinical application value, the clinical data and tumor tissue paraffin sections of 24 newly diagnosed ENKTL patients and 42 newly diagnosed diffuse large B-cell lymphoma (DLBCL) were collected. PD-1/PD-L1 levels in tumor tissues were detected by immunohistochemical staining. The relationship between the PD-1/PD-L1 levels and clinical data of patients with ENKTL patients was analyzed. Both patient groups showed PD-1 level in tumor tissue of ENKTL patients was significantly lower than that of DLBCL patients (P < 0.05), while the PD-L1 level in tumor tissues of ENKTL patients was not different from DLBCL (P < 0.05). In addition, the ENKTL patients with B symptoms, elevated lactate dehydrogenase (LDH) levels and decreased hemoglobin (HGB) concentrations had lower level of PD-1 in tumor tissue. PD-L1 level in tumor tissues, the LDH level, Epstein-Barr genome (EBV-DNA) copy and Ki-67 index may affect the outcomes of ENKTL patients (P < 0.05), but they were not independent factors. PD-L1 levels in tumor tissues has clinical significance in ENKTL patients, which suggested that the PD-1/PD-L1 signal pathway may be involved in the immune escape of ENKTL and play different roles in different lymphoma subtypes.
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影响因子：
28.5
作者：
Bi XW;Wang H;Zhang WW;Wang JH;Liu WJ;Xia ZJ;Huang HQ;Jiang WQ;Zhang YJ;Wang L
通讯作者：
Wang L
影响因子：
3.5
作者：
Jo, Jae-Cheol;Kim, Misung;Cha, Hee Jeong
通讯作者：
Cha, Hee Jeong
影响因子：
10.1
作者：
Roncador, Giovanna;Garcia Verdes-Montenegro, Jose-Francisco;Marafioti, Teresa
通讯作者：
Marafioti, Teresa
DOI：
10.1158/1078-0432.ccr-13-0855
发表时间：
2013-07-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Chen BJ;Chapuy B;Ouyang J;Sun HH;Roemer MG;Xu ML;Yu H;Fletcher CD;Freeman GJ;Shipp MA;Rodig SJ
通讯作者：
Rodig SJ
影响因子：
37.3
作者：
Rong QX;Wang F;Guo ZX;Hu Y;An SN;Luo M;Zhang H;Wu SC;Huang HQ;Fu LW
通讯作者：
Fu LW