ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS): study methodology, recruitment, and baseline demographic and disease characteristics.
ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS): study methodology, recruitment, and baseline demographic and disease characteristics.
复制标题
ALS多中心队列氧化应激研究（ALS Cosmos）：研究方法，招募和基线人口统计学和疾病特征。
DOI：
10.3109/21678421.2013.864312
复制
发表时间：
2014-06
影响因子：
2.8
通讯作者：
ALS COSMOS Study Group
中科院分区：
文献类型：
--
作者：
Mitsumoto H;Factor-Litvak P;Andrews H;Goetz RR;Andrews L;Rabkin JG;McElhiney M;Nieves J;Santella RM;Murphy J;Hupf J;Singleton J;Merle D;Kilty M;Heitzman D;Bedlack RS;Miller RG;Katz JS;Forshew D;Barohn RJ;Sorenson EJ;Oskarsson B;Fernandes Filho JA;Kasarskis EJ;Lomen-Hoerth C;Mozaffar T;Rollins YD;Nations SP;Swenson AJ;Shefner JM;Andrews JA;Koczon-Jaremko BA;ALS COSMOS Study Group
In a multicenter study of newly diagnosed ALS patients without a reported family history of ALS, we are prospectively investigating whether markers of oxidative stress (OS) are associated with disease progression. An extensive structured telephone interview ascertained environmental, lifestyle, dietary and psychological risk factors associated with OS. Detailed assessments were performed at baseline and at 3 to 6 month intervals during the ensuing 30 months. Our biorepository includes DNA, plasma, urine, and skin. 355 patients were recruited. Subjects were enrolled over a 36 month-period at 16 sites. To meet the target number of subjects, the recruitment period was prolonged and additional sites were included. Demographic and disease characteristics were similar between 477 eligible/non-enrolled and enrolled patients, with the only difference being type of health insurance among enrolled patients. Sites were divided into 3 groups by the number of enrolled subjects. Comparing these 3 groups, the Columbia site had fewer “definite ALS” diagnoses. This is the first prospective, interdisciplinary, in-depth, multicenter epidemiological investigation of OS related to ALS progression and was accomplished by an aggressive recruitment process. The baseline demographic and disease features of the study sample are now fully characterized.
登录
查看更多内容
影响因子：
4.4
作者：
Atsuta, Naoki;Watanabe, Hirohisa;Sobue, Gen
通讯作者：
Sobue, Gen
影响因子：
7.4
作者：
D'Amico, Emanuele;Factor-Litvak, Pam;Santella, Regina M.;Mitsumoto, Hiroshi
通讯作者：
Mitsumoto, Hiroshi
影响因子：
11.2
作者：
Ascherio, A;Weisskopf, MG;Thun, MJ
通讯作者：
Thun, MJ
影响因子：
11
作者：
Chio, A.;Calvo, A.;Mora, G.
通讯作者：
Mora, G.
影响因子：
--
作者：
Bedlack, Richard S.;Wicks, Paul;Kasarskis, Edward
通讯作者：
Kasarskis, Edward