Chronic rejection of human face allografts.
Chronic rejection of human face allografts.
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DOI：
10.1111/ajt.15143
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Murphy GF
中科院分区：
文献类型：
--
作者：
Krezdorn N;Lian CG;Wells M;Wo L;Tasigiorgos S;Xu S;Borges TJ;Frierson RM;Stanek E;Riella LV;Pomahac B;Murphy GF
Face vascularized composite allografts (FVCA) have helped severe patient disfigurement, with acute rejection now largely controlled through iatrogenic immunosuppression. However, little is known regarding the incidence and mechanism(s) of more long-term pathologic alterations in FVCAs that may affect function and graft durability. Protocol surveillance biopsies for up to an 8 year interval in seven patients who received FVCAs at our institution revealed histopathologic evidence of chronic rejection. Clinical manifestations included features of premature aging, mottled leukoderma accentuating suture lines, telangiectasia, and dryness of nasal mucosa. Pathologic changes consisted of epidermal thinning accompanied by discrete foci of lymphocyte-mediated cytotoxicity, hyperkeratosis, follicular plugging, vascular ectasia, and sclerosis beneath the epidermal layer associated with collagen type I deposition. Genomic interrogation and immunohistochemistry of sclerotic zones revealed upregulation of the AP-1 pathway components, JunB and c-Fos, previously implicated in overproduction of type I dermal collagen in the setting of systemic sclerosis. We conclude that some patients develop chronic rejection in FVCAs with striking similarities to alterations seen in certain autoimmune cutaneous disorders (lupus erythematosus and scleroderma/chronic sclerodermoid GVHD). Identification of relevant pathways and genes, such as JunB and c-Fos, may provide new targets into preventative therapies for chronic immune-mediated changes in vascularized composite allografts.
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影响因子：
4.6
作者：
Tachaudomdach, Chiraporn;Kantachuvesiri, Surasak;Kitiyakara, Chagriya
通讯作者：
Kitiyakara, Chagriya
影响因子：
8
作者：
Venner, Jeffery M.;Famulski, Konrad S.;Halloran, Philip F.
通讯作者：
Halloran, Philip F.
DOI：
10.1016/j.bbamcr.2013.07.016
发表时间：
2013-12-01
影响因子：
5.1
作者：
Lin, Chien-Huang;Yu, Ming-Chih;Chen, Bing-Chang
通讯作者：
Chen, Bing-Chang
影响因子：
6.2
作者：
Kanitakis, Jean;Petruzzo, Palmina;Morelon, Emmanuel
通讯作者：
Morelon, Emmanuel
同种异体移植组织中的microRNA谱和尿液配对与慢性同种异体功能障碍与IF/TA相关的。
DOI：
10.1111/j.1600-6143.2011.03666.x
发表时间：
2011-10
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Scian MJ;Maluf DG;David KG;Archer KJ;Suh JL;Wolen AR;Mba MU;Massey HD;King AL;Gehr T;Cotterell A;Posner M;Mas V
通讯作者：
Mas V