Plasmonic Biosensing with Aluminum Thin Films under the Kretschmann Configuration.
Plasmonic Biosensing with Aluminum Thin Films under the Kretschmann Configuration.
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DOI：
10.1021/acs.analchem.0c01631
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发表时间：
2020-07-07
影响因子：
7.4
通讯作者：
Cheng Q
中科院分区：
文献类型：
--
作者：
Lambert AS;Valiulis SN;Malinick AS;Tanabe I;Cheng Q
铝由于其独特的光学特性，近年来引起了人们对等离子体材料的极大兴趣，但大多数研究都局限于纳米结构。我们在这里报告了新的SPR生物传感与铝薄膜使用标准的克雷茨曼配置，以前一直由金薄膜主导。电子束物理气相沉积（EBPVD）制备的铝膜在空气中氧化形成Al2O3纳米膜，在缓冲溶液中产生强大的稳定性。时域有限差分模拟显示，在可见光范围内，等离子体急剧下降，可以测量固定角度的角移和反射强度变化。体测试和表面测试表明，铝薄膜在这两类中都表现出优异的灵敏度。与Au相比，Al/Al2O3层对人血清蛋白的非特异性结合有明显的抑制作用。进一步的表征表明，当用于SPR成像分析时，Al膜比Au膜具有更高的灵敏度和更宽的工作范围。结合其经济和制造效益，铝薄膜有潜力成为极具优势的等离子体衬底，以满足SPR配置中广泛的生物传感需求。
Aluminum has recently attracted considerable interest as plasmonic material due to its unique optical properties, but most work has been limited to nanostructures. We report here novel SPR biosensing with aluminum thin-films using the standard Kretschmann configuration that has previously been dominated by gold films. Electron-beam physical vapor deposition (EBPVD)-prepared Al films oxidize in air to form a nanofilm of Al2O3, yielding robust stability for sensing applications in buffered solutions. FDTD simulations revealed a sharp plasmonic dip in the visible range that enables measurement of both angular shift and reflection intensity change at a fixed angle. Bulk and surface tests indicated that Al films exhibited superb sensitivity performance in both categories. Compared to Au, the Al/Al2O3 layer showed a marked effect of suppressing non-specific binding from proteins in human serum. Further characterization indicated that Al film demonstrated a higher sensitivity and a wider working range than Au films when used for SPR imaging analysis. Combined with its economic and manufacturing benefits, the Al thin-film has the potential to become a highly advantageous plasmonic substrate to meet a wide range of biosensing needs in SPR configurations.
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影响因子：
7.4
作者：
Abbas, Abdennour;Linman, Matthew J.;Cheng, Quan
通讯作者：
Cheng, Quan
影响因子：
10.8
作者：
Hobbs, Richard G.;Manfrinato, Vitor R.;Berggren, Karl K.
通讯作者：
Berggren, Karl K.
影响因子：
4.6
作者：
Beeg, Marten;Nobili, Alessandro;Gobbi, Marco
通讯作者：
Gobbi, Marco
DOI：
10.1016/s0927-7757(00)00821-9
发表时间：
2001-06-30
影响因子：
5.2
作者：
Karaman, ME;Antelmi, DA;Pashley, RM
通讯作者：
Pashley, RM
影响因子：
1
作者：
Arora, Pankaj;Awasthi, Harsh V.
通讯作者：
Awasthi, Harsh V.