Fish oil, selenium and mercury in relation to incidence of hypertension: a 20-year follow-up study.
Fish oil, selenium and mercury in relation to incidence of hypertension: a 20-year follow-up study.
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DOI：
10.1111/j.1365-2796.2010.02338.x
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发表时间：
2011-08
影响因子：
11.1
通讯作者：
He K
中科院分区：
文献类型：
--
作者：
Xun P;Hou N;Daviglus M;Liu K;Morris JS;Shikany JM;Sidney S;Jacobs DR;He K
长链omega-3多不饱和脂肪酸（LCω3PUFA）、硒（Se）和汞（Hg）是鱼类中的三种重要成分。摄入 LCω3PUFA 的心脏保护作用已得到认可；然而，高硒和低汞水平可能带来最大益处的假设尚未得到研究。研究纳入了 4,508 名 18-30 岁美国成年人，1985 年基线时没有高血压。在 1987 年、1990 年、1992 年、1995 年、2000 年和 2005 年的检查中进行了六次随访。在 1985 年、1992 年和 2005 年的检查中，通过经过验证的访调员管理的定量食物频率问卷对饮食进行了评估。高血压事件的定义是在任何后续检查中首次出现收缩压≥140 mmHg，舒张压≥90mmHg，或正在服用抗高血压药物。 1987 年收集了剪下的脚趾甲，并通过仪器中子活化分析对 Se 和 Hg 水平进行了定量。调整潜在混杂因素后，与最低四分位数的参与者相比，LCω3PUFA摄入量最高四分位数的参与者的高血压发病率显着降低（风险比：0.65；95% CI：0.53-0.79；Ptrend<0.01）。二十二碳六烯酸表现出比二十碳五烯酸更大的负相关性。尽管相互作用测试在统计上不显着，但在较高的硒和较低的汞水平下，LCω3PUFA 摄入量与高血压的负相关性似乎更为明显。研究结果表明，LCω3PUFA 的摄入量与高血压的发病率呈负相关。先前的假设是，LCω3PUFA 摄入量的潜在抗高血压作用根据 Se 和 Hg 的联合水平而变化，这一假设得到了适度的支持，并且不能被排除。
Long-chain omega-3 polyunsaturated fatty acids (LCω3PUFAs), selenium (Se) and mercury (Hg) are three important components in fish. The cardioprotective effect of LCω3PUFA intake has been recognized; however, the hypothesis that this benefit may be greatest with high Se and low Hg levels has not been investigated. A cohort of 4,508 American adults aged 18–30, without hypertension at baseline in 1985, were enrolled. Six follow-ups were conducted at exams in 1987, 1990, 1992, 1995, 2000 and 2005. Diet was assessed by a validated interviewer-administered quantitative food frequency questionnaire at exams in 1985, 1992 and 2005. Incident hypertension was defined as first occurrence at any follow-up examination of systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg, or taking anti-hypertensive medication. Toenail clippings were collected in 1987, and Se and Hg levels were quantified by instrumental neutron-activation analysis. Participants in the highest LCω3PUFAintake quartile had a significantly lower incidence of hypertension (Hazard Ratio: 0.65; 95% CI: 0.53–0.79; Ptrend<0.01) compared to those in the lowest quartile after adjustment for potential confounders. Docosahexaenoic acid showed a greater inverse association than eicosapentaenoic acid. The inverse association of LCω3PUFA intake with hypertension appeared more pronounced at higher Se and lower Hg levels, although interaction tests were statistically non-significant. Out findings indicated that LCω3PUFA intake was inversely associated with incidence of hypertension. The prior hypothesis that the potential anti-hypertensive effect of LCω3PUFA intake varies depending on joint levels of Se and Hg received modest support, and cannot be ruled out.
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影响因子：
5.4
作者：
GREENLAND, S
通讯作者：
GREENLAND, S
影响因子：
120.7
作者：
HUNTER, DJ;MORRIS, JS;WILLETT, WC
通讯作者：
WILLETT, WC
DOI：
10.1016/s0169-2607(97)00043-6
发表时间：
1997-11-01
影响因子：
6.1
作者：
Heinzl, H;Kaider, A
通讯作者：
Kaider, A
影响因子：
3.9
作者：
Frisk, P;Wester, K;Lindh, U
通讯作者：
Lindh, U
影响因子：
7.2
作者：
Gunderson EP;Chiang V;Lewis CE;Catov J;Quesenberry CP Jr;Sidney S;Wei GS;Ness R
通讯作者：
Ness R