RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer.

RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer.
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DOI:
10.1038/sj.bjc.6602119
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发表时间:
2004-09-13
影响因子:
8.8
通讯作者:
--
中科院分区:
医学1区
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--
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环加氧酶(特别是 Cox-2)参与癌发生和转移性癌症进展。环氧合酶的表达谱及其在相似阶段的已形成肿瘤中发挥的作用仍不清楚。我们报告说,Cox-1 和 Cox-2 表达在 Dukes' C 肿瘤中高度可变,并且 Cox-1 表达的变化可能很重要。
Cyclooxygenases (particularily Cox-2) are involved in carcinogenesis and metastatic cancer progression. The expression profiles of the cyclooxygenases and the roles they play in established tumours of similar stage remains unclear. We report that Cox-1 and Cox-2 expression is highly variable in Dukes' C tumours, and changes in Cox-1 expression may be of importance.
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