Analysis of ageing-associated grey matter volume in patients with multiple sclerosis shows excess atrophy in subcortical regions.
Analysis of ageing-associated grey matter volume in patients with multiple sclerosis shows excess atrophy in subcortical regions.
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DOI：
10.1016/j.nicl.2016.11.005
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发表时间：
2017
影响因子：
4.2
通讯作者：
Waldman, Adam D.
中科院分区：
文献类型：
--
作者：
Bishop, Courtney A.;Newbould, Rexford D.;Lee, Jean S. Z.;Honeyfield, Lesley;Quest, Rebecca;Colasanti, Alessandro;Ali, Rehiana;Mattoscio, Miriam;Cortese, Antonio;Nicholas, Richard;Matthews, Paul M.;Muraro, Paolo A.;Waldman, Adam D.
多发性硬化症（MS）的发病年龄对病程有影响。这项研究检查了“年轻”和“年长”发病的MS受试者之间的整体和区域脑容量是否存在差异，这些受试者的疾病持续时间较短，平均1.9年，负担（由MS严重程度评分和复发衡量）。21例年轻发病的MS患者（年龄30.4±3.2岁）与17例高龄发病的MS患者（年龄48.7±3.3岁）以及年龄匹配的对照组（n = 31、31.9±3.5岁和n = 21、47.3±4.0岁）进行比较。所有受试者均行三维体积T1和T2-FLAIR成像。白质（WM）和灰质（GM）病变手工勾画。在组织和结构分割之前填充病变以减少分类错误。与对照组相比，体积损失主要发生在皮质下GM，约为0.13%。年轻和老年发病的MS受试者在壳核、丘脑和伏隔核中有相似的、强烈的过度损失。杏仁核和苍白体未发现过度的损失。海马体和尾状核在年轻组中表现出明显的过度损失（p < 0.001），在老年发病组中表现出强烈的趋势。这些结果为已发表的神经心理学研究提供了潜在的成像相关性，这些研究报告了发病年龄越小与认知能力受损（包括工作记忆下降）之间的关联。在MS早期，皮质下GM萎缩是皮质GM萎缩的三倍以上。相比之下，WM和皮质GM没有表现出与对照组相比的过度萎缩。临床匹配的年轻与老年发病多发性硬化症的海马萎缩提出了多发性硬化症成像数据萎缩分析的工作流程
Age of onset in multiple sclerosis (MS) exerts an influence on the course of disease. This study examined whether global and regional brain volumes differed between “younger” and “older” onset MS subjects who were matched for short disease duration, mean 1.9 years and burden as measured by the MS Severity Score and relapses. 21 younger-onset MS subjects (age 30.4 ± 3.2 years) were compared with 17 older-onset (age 48.7 ± 3.3 years) as well as age-matched controls (n = 31, 31.9 ± 3.5 years and n = 21, 47.3 ± 4.0 years). All subjects underwent 3D volumetric T1 and T2-FLAIR imaging. White matter (WM) and grey matter (GM) lesions were outlined manually. Lesions were filled prior to tissue and structural segmentation to reduce classification errors. Volume loss versus control was predominantly in the subcortical GM, at > 13% loss. Younger and older-onset MS subjects had similar, strong excess loss in the putamen, thalamus, and nucleus accumbens. No excess loss was detected in the amygdala or pallidum. The hippocampus and caudate showed significant excess loss in the younger group (p < 0.001) and a strong trend in the older-onset group. These results provide a potential imaging correlate of published neuropsychological studies that reported the association of younger age at disease onset with impaired cognitive performance, including decreased working memory. Compared brain atrophy within MS cohort differing only by age, and matched controls In early MS, subcortical GM atrophy is more than three times that of cortical GM. By contrast, WM and cortical GM do not show excess atrophy compared with controls. Hippocampal atrophy noted for clinically-matched younger versus older onset MS Proposed workflow for atrophy analysis of imaging data in MS
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影响因子：
5.7
作者：
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通讯作者：
Smith, S
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Geurts, Jeroen J. G.
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9.9
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Roxburgh, RHSR;Seaman, SR;Compston, DAS
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Compston, DAS