Anthelmintics for drug repurposing: Opportunities and challenges.
Anthelmintics for drug repurposing: Opportunities and challenges.
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毒品重新利用的驱虫药：机遇和挑战。
DOI：
10.1016/j.jsps.2021.04.004
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Ebrahimi Shahmabadi H
中科院分区：
文献类型：
--
作者：
Alavi SE;Ebrahimi Shahmabadi H
药物重新定位被定义为确定药物新应用的过程。这种方法至关重要，因为它利用了众所周知的药物药代动力学、药效学和毒性特征；因此，它们未来失败的机会就会减少，开发成本和批准所需的时间也会减少。驱虫药是一种抗寄生虫药物，最近在体外和体内表现出有希望的抗癌作用。本文献综述重点关注驱虫药在癌症治疗中重新定位的潜力。它还讨论了它们作为抗寄生虫药物的药代动力学和药效学、提出的抗癌机制、目前的开发条件、癌症治疗的挑战以及克服这些挑战的策略。
Drug repositioning is defined as a process to identify a new application for drugs. This approach is critical as it takes advantage of well-known pharmacokinetics, pharmacodynamics, and toxicity profiles of the drugs; thus, the chance of their future failure decreases, and the cost of their development and the required time for their approval are reduced. Anthelmintics, which are antiparasitic drugs, have recently demonstrated promising anticancer effects in vitro and in vivo. This literature review focuses on the potential of anthelmintics for repositioning in the treatment of cancers. It also discusses their pharmacokinetics and pharmacodynamics as antiparasitic drugs, proposed anticancer mechanisms, present development conditions, challenges in cancer therapy, and strategies to overcome these challenges.
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