Oxygen-related chemoreceptor drive to breathe during H₂S infusion.
Oxygen-related chemoreceptor drive to breathe during H₂S infusion.
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DOI：
10.1016/j.resp.2014.05.012
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发表时间：
2014-09-15
影响因子：
2.3
通讯作者：
Chenuel, Bruno
中科院分区：
文献类型：
--
作者：
Haouzi, Philippe;Sonobe, Takashi;Chenuel, Bruno
这项研究解决了以下问题：高氧引起的急性呼吸抑制，反映了动脉化学感受器对呼吸的紧张性驱动，是否可以通过局部内源性硫化氢的背景水平来解释？为了解决这个问题，我们通过持续注入低水平的H_2S，在10只乌拉坦镇静自主呼吸的大鼠中产生了稳定但适度的呼吸增加(24±11%)。我们发现，在对照条件下，急性暴露于100%O2(20次)在15秒内使每分钟通气量(VI)从301±51降至210±43ml/min，但在H_2S诱导的高呼吸期间，VI没有进一步显著下降。此外，在高氧测试期间，动脉血中气体硫化氢的估计浓度没有下降。结论：高氧诱导的呼吸抑制似乎仅限于紧张性背景的外周化学感觉呼吸驱动，而对低浓度H_2S产生的CB刺激影响很小或没有影响。
This study addresses the following question: Could the acute depression in breathing produced by hyperoxia, a reflection of the tonic drive to breathe from the arterial chemoreceptors, be accounted for by the presence a background level of local endogenous H2S? To address this question, we produced a stable but moderate increase in breathing (24 ± 11%) via continuous infusion of low levels of H2S, in 10 spontaneously breathing urethane-sedated rats. We found that acute exposure to 100% O2 (20 tests) decreased minute ventilation (VI) from 301 ± 51 to 210 ± 43 ml/min within 15 seconds in control conditions, but no additional significant drop in VI was observed during H2S induced hyperpnea. In addition, no decrease in the estimated concentrations of gaseous H2S in the arterial blood was observed during the hyperoxic tests. It is concluded that the ventilatory depression induced by high O2 appears to be limited to the tonic background peripheral chemosensory drive to breathe, but has little or no impact on the CB stimulation produced by low levels of H2S.
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DOI：
10.1016/0198-0149(79)90023-2
发表时间：
1979-01-01
期刊：
DEEP-SEA RESEARCH PART A-OCEANOGRAPHIC RESEARCH PAPERS
影响因子：
--
作者：
DOUABUL, AA;RILEY, JP
通讯作者：
RILEY, JP
影响因子：
2.3
作者：
Haouzi, Philippe;Van de Louw, Andry
通讯作者：
Van de Louw, Andry
影响因子：
2.3
作者：
Haouzi, Philippe;Bell, Harold;Philmon, Maeve
通讯作者：
Philmon, Maeve
硫化氢介导的新生大鼠髓质切片呼吸节律的中枢调节
影响因子：
3.3
作者：
Chen, L.;Zhang, J.;Zheng, Y.
通讯作者：
Zheng, Y.
DOI：
10.1073/pnas.1202916109
发表时间：
2012-06-05
影响因子：
11.1
作者：
Coletta, Ciro;Papapetropoulos, Andreas;Szabo, Csaba
通讯作者：
Szabo, Csaba