Downstream of identity genes: muscle-type-specific regulation of the fusion process.
Downstream of identity genes: muscle-type-specific regulation of the fusion process.
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DOI：
10.1016/j.devcel.2010.07.008
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发表时间：
2010-08-17
影响因子：
11.8
通讯作者：
Jagla, Krzysztof
中科院分区：
文献类型：
--
作者：
Bataille, Laetitia;Delon, Isabelle;Da Ponte, Jean Philippe;Brown, Nicholas H.;Jagla, Krzysztof
In all metazoan organisms, the diversification of cell types involves determination of cell fates and subsequent execution of specific differentiation programmes. During Drosophila myogenesis, identity genes specify the fates of founder myoblasts, from which derive all individual larval muscles. Here, to understand how cell fate information residing within founders is translated during differentiation, we focus on three identity genes, eve, lb and slou and how they control the size of individual muscles by regulating the number of fusion events. They achieve this by setting expression levels of Mp20, Pax and mspo, three genes that regulate actin dynamics and cell adhesion and, as we show here, modulate the fusion process in a muscle-specific manner. Thus, these data provide the first example of how the identity information implemented by transcription factors is translated via target genes into cell-type specific programmes of differentiation.
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影响因子：
4.6
作者：
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通讯作者：
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影响因子：
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DOI：
10.1083/jcb.135.4.1109
发表时间：
1996-11
期刊：
The Journal of cell biology
影响因子：
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3.3
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10.1016/j.biocel.2004.01.002
发表时间：
2004-06-01
影响因子：
4
作者：
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通讯作者：
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