Keeping at arm's length during regeneration.

Keeping at arm's length during regeneration.
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DOI:
10.1016/j.devcel.2014.04.007
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发表时间:
2014-04-28
期刊:
影响因子:
11.8
通讯作者:
Poss, Kenneth D.
Poss, Kenneth D.
中科院分区:
生物学1区
文献类型:
--
作者:
Tornini, Valerie A.;Poss, Kenneth D.

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在成年两栖动物和鱼类中,失去的附肢的再生是发育模式的一个显着壮举。虽然肢体或鳍可能是从胚胎原基的最初创造中移走了几年,但在受伤部位出现的芽基形成了一个接近成年形式的模仿。理解这些事件的核心是揭示新结构的细胞起源,位置同一性是如何保持的,以及完成的决定因素。这些主题中的每一个最近都得到了发展,加强了在成人背景下如何回忆复杂组织模式的模型。
Regeneration of a lost appendage in adult amphibians and fish is a remarkable feat of developmental patterning. Although the limb or fin may be years removed from its initial creation by an embryonic primordium, the blastema that emerges at the injury site fashions a close mimic of adult form. Central to understanding these events are revealing the cellular origins of new structures, how positional identity is maintained, and the determinants for completion. Each of these topics has been advanced recently, strengthening models for how complex tissue pattern is recalled in the adult context.
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