Differential brain responses to cries of infants with autistic disorder and typical development: an fMRI study.
Differential brain responses to cries of infants with autistic disorder and typical development: an fMRI study.
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DOI：
10.1016/j.ridd.2012.06.011
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发表时间：
2012-11
影响因子：
3.1
通讯作者：
de Falco S
中科院分区：
文献类型：
--
作者：
Venuti P;Caria A;Esposito G;De Pisapia N;Bornstein MH;de Falco S
这项研究使用功能性磁共振成像来测量成人处理自闭症（AD）婴儿的哭声时的大脑活动，并与正常发育（TD）婴儿的哭声进行比较。使用全脑分析，我们发现，与TD婴儿相比，AD婴儿的哭声引起了与言语和韵律处理相关的大脑区域的活动增强，这可能是因为AD哭声的声学模式改变使它们特别难以解释，并且与情绪处理相关的大脑区域的活动增加，这表明AD哭声也会引起更多的负面感觉，并且可能被认为是更令人厌恶和/或更令人兴奋。由AD哭泣引起的感知痛苦与与情绪处理相关的大脑区域的激活增加有关。这项研究支持这一假设，哭是一个早期和有意义的异常显示的儿童与AD。这可能是与AD相关的哭声改变亲子互动的时间比可靠的AD诊断通常发生的时间早得多。
This study used fMRI to measure brain activity during adult processing of cries of infants with autistic disorder (AD) compared to cries of typically developing (TD) infants. Using whole brain analysis, we found that cries of infants with AD compared to those of TD infants elicited enhanced activity in brain regions associated with verbal and prosodic processing, perhaps because altered acoustic patterns of AD cries render them especially difficult to interpret, and increased activity in brain regions associated with emotional processing, indicating that AD cries also elicit more negative feelings and may be perceived as more aversive and/or arousing. Perceived distress engendered by AD cries related to increased activation in brain regions associated with emotional processing. This study supports the hypothesis that cry is an early and meaningful anomaly displayed by children with AD. It could be that cries associated with AD alter parent-child interactions much earlier than the time that reliable AD diagnosis normally occurs.
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影响因子：
3.1
作者：
Esposito G;Nakazawa J;Venuti P;Bornstein MH
通讯作者：
Bornstein MH
影响因子：
10.6
作者：
Caria, Andrea;Sitaram, Ranganatha;Birbaumer, Niels
通讯作者：
Birbaumer, Niels
影响因子：
1.7
作者：
Esposito, Gianluca;Venuti, Paola;Muratori, Filippo
通讯作者：
Muratori, Filippo
影响因子：
3.5
作者：
Fleming, AS;Corter, C;Steiner, M
通讯作者：
Steiner, M
影响因子：
2.1
作者：
Dessureau, BK;Kurowski, CO;Thompson, NS
通讯作者：
Thompson, NS