Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption.
Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption.
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DOI：
10.3390/nu14214645
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发表时间：
2022-11-03
期刊：
影响因子：
5.9
通讯作者：
Marcinek DJ
中科院分区：
文献类型：
--
作者：
Valencia AP;Whitson JA;Wang S;Nguyen L;den Hartigh LJ;Rabinovitch PS;Marcinek DJ
衰老和不良饮食是心脏病的独立危险因素，但高蔗糖 (HS) 消耗对衰老心脏的影响尚未得到充分研究。衰老会导致线粒体功能受损，从而导致肌肉功能障碍（例如心脏重塑和肌肉减少症）。我们测试了 HS 饮食（60%kcal 蔗糖）是否会加速 24 个月大的雄性 CB6F1 小鼠的肌肉功能障碍。到 HS 饮食的第一周，与年龄匹配的食物喂养对照组相比，小鼠出现了明显的心脏肥大。在整个 4 周的治疗过程中，心脏重量持续增加，而体重和力量下降得比对照组更快。然后，我们测试了 HS 饮食是否会加重老年小鼠的心脏功能障碍，以及线粒体靶向药物埃拉米肽 (ELAM) 是否可以阻止饮食引起的影响。年老和年轻的小鼠均接受 ELAM 或生理盐水治疗 2 周作为对照，并在最后一周提供 HS 饮食或食物。正如之前的实验所证明的，老年小鼠患有与年龄相关的心脏肥大，在 HS 治疗一周后病情恶化，并通过 ELAM 治疗得到预防，而 HS 饮食对年轻小鼠的心脏肥大没有可检测到的影响。正如预期的那样，线粒体呼吸和活性氧 (ROS) 产生随年龄而改变，但不受 HS 饮食或 ELAM 的显着影响。我们的研究结果强调了老年心脏对 HS 饮食的脆弱性，可以通过用 ELAM 系统性靶向线粒体来预防。
Aging and poor diet are independent risk factors for heart disease, but the impact of high-sucrose (HS) consumption in the aging heart is understudied. Aging leads to impairments in mitochondrial function that result in muscle dysfunction (e.g., cardiac remodeling and sarcopenia). We tested whether HS diet (60%kcal sucrose) would accelerate muscle dysfunction in 24-month-old male CB6F1 mice. By week 1 on HS diet, mice developed significant cardiac hypertrophy compared to age-matched chow-fed controls. The increased weight of the heart persisted throughout the 4-week treatment, while body weight and strength declined more rapidly than controls. We then tested whether HS diet could worsen cardiac dysfunction in old mice and if the mitochondrial-targeted drug, elamipretide (ELAM), could prevent the diet-induced effect. Old and young mice were treated with either ELAM or saline as a control for 2 weeks, and provided with HS diet or chow on the last week. As demonstrated in the previous experiment, old mice had age-related cardiac hypertrophy that worsened after one week on HS and was prevented by ELAM treatment, while the HS diet had no detectable effect on hypertrophy in the young mice. As expected, mitochondrial respiration and reactive oxygen species (ROS) production were altered by age, but were not significantly affected by HS diet or ELAM. Our findings highlight the vulnerability of the aged heart to HS diet that can be prevented by systemic targeting of the mitochondria with ELAM.
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影响因子：
16.6
作者：
通讯作者：
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影响因子：
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作者：
Pavillard LE;Cañadas-Lozano D;Alcocer-Gómez E;Marín-Aguilar F;Pereira S;Robertson AAB;Muntané J;Ryffel B;Cooper MA;Quiles JL;Bullón P;Ruiz-Cabello J;Cordero MD
通讯作者：
Cordero MD
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影响因子：
2.5
作者：
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影响因子：
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作者：
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影响因子：
7.3
作者：
Birk, A. V.;Chao, W. M.;Szeto, H. H.
通讯作者：
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