De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health.
De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health.
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DOI：
10.1038/ncomms2537
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发表时间：
2013
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
最近在啮齿动物中的研究表明，从头脂肪生成特别是在白色脂肪组织中产生胰岛素增敏脂肪酸棕榈油酸酯，这激发了对从头脂肪生成的临床兴趣。相比之下，肝脏脂肪生成被认为有助于代谢疾病。在人类肥胖和胰岛素抵抗中，白色脂肪组织相对于肝脏的新生脂肪生成是如何改变的，目前还知之甚少。在这里，我们发现，脂肪生成酶和葡萄糖转运蛋白-4显着减少，在白色脂肪组织的胰岛素抵抗肥胖的个人相比，非肥胖的控制。相比之下，脂肪生成酶在肥胖受试者的肝脏中显著上调。减肥恢复了白色脂肪组织的脂肪生成和葡萄糖转运蛋白4基因表达。值得注意的是，白色脂肪组织和肝脏中的脂肪生成基因表达与碳水化合物反应元件结合蛋白-β的表达和代谢风险标志物密切相关。因此，从头脂肪生成以组织特异性方式预测人类的代谢健康，并且可能受到葡萄糖依赖性碳水化合物响应元件结合蛋白激活的调节。
Clinical interest in de novo lipogenesis has been sparked by recent studies in rodents demonstrating that de novo lipogenesis specifically in white adipose tissue produces the insulin-sensitizing fatty acid palmitoleate. By contrast, hepatic lipogenesis is thought to contribute to metabolic disease. How de novo lipogenesis in white adipose tissue versus liver is altered in human obesity and insulin resistance is poorly understood. Here we show that lipogenic enzymes and the glucose transporter-4 are markedly decreased in white adipose tissue of insulin-resistant obese individuals compared with non-obese controls. By contrast, lipogenic enzymes are substantially upregulated in the liver of obese subjects. Bariatric weight loss restored de novo lipogenesis and glucose transporter-4 gene expression in white adipose tissue. Notably, lipogenic gene expression in both white adipose tissue and liver was strongly linked to the expression of carbohydrate-responsive element-binding protein-β and to metabolic risk markers. Thus, de novo lipogenesis predicts metabolic health in humans in a tissue-specific manner and is likely regulated by glucose-dependent carbohydrate-responsive element-binding protein activation.
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影响因子：
64.5
作者：
Cao H;Gerhold K;Mayers JR;Wiest MM;Watkins SM;Hotamisligil GS
通讯作者：
Hotamisligil GS
影响因子：
82.9
作者：
Erbay, Ebru;Babaev, Vladimir R.;Mayers, Jared R.;Makowski, Liza;Charles, Khanichi N.;Snitow, Melinda E.;Fazio, Sergio;Wiest, Michelle M.;Watkins, Steven M.;Linton, MacRae F.;Hotamisligil, Goekhan S.
通讯作者：
Hotamisligil, Goekhan S.
影响因子：
29
作者：
Farese RV Jr;Zechner R;Newgard CB;Walther TC
通讯作者：
Walther TC
影响因子：
7.1
作者：
Gong, Jian;Campos, Hannia;Baylin, Ana
通讯作者：
Baylin, Ana
影响因子：
5.6
作者：
Hudgins, Lisa C.;Baday, Aline;Hirsch, Jules
通讯作者：
Hirsch, Jules