Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer's Disease.
Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer's Disease.
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DOI：
10.1002/msj.20160
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发表时间：
2010-01
影响因子：
--
通讯作者：
Gandy, Sam
中科院分区：
文献类型：
--
作者：
Lublin, Alex L.;Gandy, Sam
阿尔茨海默病是老年性痴呆最常见的形式。尽管β - 淀粉样肽在1984年被确定为该疾病特征性老年斑的主要成分，但越来越多的证据表明，斑块密度与同时期的疾病状态并不十分相符。为了解决这种脱节现象，最近的一些研究已经从老年斑和经典的纤维状淀粉样蛋白形式转向一种结构不太明确的物质，将其作为阿尔茨海默病认知障碍背后的直接神经毒性因子：可溶性β - 淀粉样肽寡聚体（也称为β - 淀粉样肽衍生的可扩散配体）。矛盾的是，过去两年的几项研究表明，皮摩尔水平的β - 淀粉样肽具有中性活性，甚至可能在学习和记忆中起着至关重要的作用。在此，我们重点介绍一些促使人们日益关注β - 淀粉样肽寡聚体的关键观察结果。
Alzheimer’s disease is the most common form of senile dementia. Although the amyloid-β peptide was identified in 1984 as the major constituent of the senile plaques that characterize the disease, accumulating evidence indicates that the plaque density does not correspond well to the concurrent disease state. In order to resolve this disconnect, a number of recent studies have shifted away from the senile plaque and classical fibrillar forms of amyloid toward a less well structured species as the proximate neurotoxic factor underlying cognitive failure in Alzheimer’s disease: soluble amyloid-β peptide oligomer (also known as the amyloid-β peptide–derived diffusible ligand). Paradoxically, several studies in the last 2 years have shown that picomolar levels of amyloid-β peptide have neutral activity or perhaps even an essential role in learning and memory. Here we highlight some of the key observations underlying the growing focus on the amyloid-β peptide oligomer.
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影响因子：
120.7
作者：
Näslund, J;Haroutunian, V;Buxbaum, JD
通讯作者：
Buxbaum, JD
影响因子：
--
作者：
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影响因子：
25
作者：
Cleary, JP;Walsh, DM;Ashe, KH
通讯作者：
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DOI：
10.1073/pnas.95.11.6448
发表时间：
1998-05-26
影响因子：
11.1
作者：
Lambert, MP;Barlow, AK;Klein, WL
通讯作者：
Klein, WL
影响因子：
5.3
作者：
Giuffrida, Maria Laura;Caraci, Filippo;Copani, Agata
通讯作者：
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