Frequent amyloid deposition without significant cognitive impairment among the elderly.
Frequent amyloid deposition without significant cognitive impairment among the elderly.
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DOI：
10.1001/archneur.65.11.1509
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发表时间：
2008-11
影响因子：
--
通讯作者：
Klunk, William E.
中科院分区：
文献类型：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通过匹兹堡化合物B（PiB）正电子发射断层扫描（PET）成像评估，描述临床未受损老年人群中淀粉样蛋白沉积的患病率，并通过一系列神经心理学测试测量其与认知功能的关系。受试者接受认知测试和PiB PET成像（使用ECAT HR+扫描仪，15 mCi，持续90分钟）。Logan图形分析用于估计区域PiB滞留分布体积，归一化为小脑参考区域体积，以产生分布体积比（DVR）。大学医疗中心从基于社区的志愿者样本中，纳入了43名年龄在65至88岁之间的参与者，他们不符合阿尔茨海默病或轻度认知障碍的诊断标准。区域PiB保持和认知测试表现。在43名临床未受损的老年人中，9名（21%）使用客观确定的DVR截止值显示至少1个脑区中存在早期淀粉样蛋白沉积的证据。淀粉样蛋白阳性和淀粉样蛋白阴性参与者之间的人口统计学特征没有显著差异，与淀粉样蛋白阴性参与者相比，淀粉样蛋白阳性参与者的神经认知表现并没有显著差。淀粉样蛋白沉积可以在认知正常的老年人中发现，无症状的淀粉样蛋白沉积的患病率可能与有症状的淀粉样蛋白沉积相似。在这组没有临床显着损害的参与者中，淀粉样蛋白沉积与认知功能恶化无关，这表明淀粉样蛋白负担严重的老年人可以保持认知正常。然而，这一发现是基于相对较小的数字，需要在更大的队列中复制。需要对这些受试者进行纵向随访，以支持PiB成像识别临床前阿尔茨海默病的潜力，或者显示淀粉样蛋白沉积不足以在某些特定时期内引起阿尔茨海默病。
To characterize the prevalence of amyloid deposition in a clinically unimpaired elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission tomography (PET) imaging, and its relationship to cognitive function, measured with a battery of neuropsychological tests. Subjects underwent cognitive testing and PiB PET imaging (15 mCi for 90 minutes with an ECAT HR + scanner). Logan graphical analysis was applied to estimate regional PiB retention distribution volume, normalized to a cerebellar reference region volume, to yield distribution volume ratios (DVRs). University medical center. From a community-based sample of volunteers, 43 participants aged 65 to 88 years who did not meet diagnostic criteria for Alzheimer disease or mild cognitive impairment were included. Regional PiB retention and cognitive test performance. Of 43 clinically unimpaired elderly persons imaged, 9 (21%) showed evidence of early amyloid deposition in at least 1 brain area using an objectively determined DVR cutoff. Demographic characteristics did not differ significantly between amyloid-positive and amyloid-negative participants, and neurocognitive performance was not significantly worse among amyloid-positive compared with amyloid-negative participants. Amyloid deposition can be identified among cognitively normal elderly persons during life, and the prevalence of asymptomatic amyloid deposition may be similar to that of symptomatic amyloid deposition. In this group of participants without clinically significant impairment, amyloid deposition was not associated with worse cognitive function, suggesting that an elderly person with a significant amyloid burden can remain cognitively normal. However, this finding is based on relatively small numbers and needs to be replicated in larger cohorts. Longitudinal follow-up of these subjects will be required to support the potential of PiB imaging to identify preclinical Alzheimer disease, or, alternatively, to show that amyloid deposition is not sufficient to cause Alzheimer disease within some specified period.
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影响因子：
9.9
作者：
Lopez, OL;Becker, JT;DeKosky, ST
通讯作者：
DeKosky, ST
影响因子：
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作者：
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120.7
作者：
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作者：
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通讯作者：
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影响因子：
11.2
作者：
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通讯作者：
Långström, B