The effect of fibrin sealant on the healing of laser-resurfaced skin.
The effect of fibrin sealant on the healing of laser-resurfaced skin.
复制标题
纤维蛋白密封剂对激光表面修复皮肤愈合的影响。
作者：
Joseph B. Eby;R.Antonio Navarro;Andrea Dunkelman;Josh Lichtman;M. C. Fishbein;J. Aronowitz;D. Kulber
背景
止血封合剂是一种有效的止血剂和有用的组织封合剂。研究还表明，纤维蛋白封闭剂可以加速正常的伤口愈合过程。
目的
本研究旨在确定纤维蛋白封闭剂是否会促进豚鼠模型中CO（2）激光表面置换后的伤口愈合。
方法
使用CO（2）激光在14只Dunkin Hartley豚鼠的两侧创建相等面积的皮肤表面置换。治疗侧应用纤维素封闭剂，而对照侧应用杆菌肽。在第1、3、7和10天对这些区域进行活检。使用分级量表进行组织学评价，比较急性和慢性炎症、肉芽组织、胶原沉积和表皮再生。
结果
用纤维蛋白封闭剂治疗的伤口显示急性和慢性炎症程度以及胶原蛋白沉积在统计学上显著降低。在第7天，观察到纤维蛋白封闭剂增强了新血管形成，并导致上皮再形成轻微延迟。所有伤口在第10天完全上皮化。未观察到因应用纤维蛋白封闭剂而导致的伤口感染或其他并发症。
结论
虽然伤口愈合没有加速，但在CO（2）激光表面置换术后应用纤维蛋白封闭剂减少了急性和慢性炎症反应，增强了新血管形成，并减少了胶原蛋白积聚。需要进一步的研究来评估本研究中提到的纤维蛋白封闭剂的作用是否会改善CO（2）激光表面置换术后的外观愈合。（Aesthetic Surg J 2001;21：509-517.）。
BACKGROUND
Fibrin sealant is an effective hemostatic agent and a useful tissue sealant. Studies have also suggested that fibrin sealant may accelerate the normal wound-healing process.
OBJECTIVE
This study was designed to ascertain whether fibrin sealant would enhance wound healing after CO(2) laser resurfacing in a guinea pig model.
METHODS
The CO(2) laser was used to create equal areas of skin resurfacing on both sides of 14 Dunkin Hartley guinea pigs. Fibrin sealant was applied to the treatment side, whereas bacitracin was applied to the control side. Biopsies of these areas were performed on days 1, 3, 7, and 10. A histologic evaluation was performed with the use of a grading scale that compared acute and chronic inflammation, granulation tissue, collagen deposition, and epidermal regeneration.
RESULTS
The wounds treated with fibrin sealant demonstrated a statistically significant reduction in the degree of acute and chronic inflammation as well as collagen deposition. At day 7, fibrin sealant was noted to enhance neovascularization and result in a slight delay in reepithelialization. All wounds were completely reepithelialized at day 10. No wound infections or other complications were noted as a result of the application of fibrin sealant.
CONCLUSIONS
Although wound healing was not accelerated, the application of fibrin sealant after CO(2) laser resurfacing diminished the acute and chronic inflammatory response, enhanced neovascularization, and reduced collagen accumulation. Further research is needed to assess whether the effects of fibrin sealant noted in this study result in improved cosmetic healing after CO(2) laser resurfacing. (Aesthetic Surg J 2001;21:509-517.).
影响因子：
3.8
作者：
T. K. Hunt;D. Knighton;K. K. Thakral-K.;W. Goodson;W. Andrews
通讯作者：
T. K. Hunt;D. Knighton;K. K. Thakral-K.;W. Goodson;W. Andrews
DOI：
--
发表时间：
1986
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
P. S. Ciano;R. Colvin;A. Dvorak;J. McDonagh;H. Dvorak
通讯作者：
P. S. Ciano;R. Colvin;A. Dvorak;J. McDonagh;H. Dvorak
影响因子：
9
作者：
Rotstein,OD;Pruett,TL;Simmons,RL
通讯作者：
Simmons,RL