MicroRNAs and glial cell development.

MicroRNAs and glial cell development.
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MicroRNA 和神经胶质细胞发育

DOI:
10.1177/1073858411398322
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发表时间:
2012-04
期刊:
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子:
--
通讯作者:
Qiu M
Qiu M
中科院分区:
其他
文献类型:
--
作者:
Zheng K;Li H;Huang H;Qiu M

文献摘要

参考文献

相似文献

越来越多的证据表明microRNAs(miRNAs)在中枢神经系统胶质细胞发育的调控中发挥重要作用。抑制miRNA的形成破坏了胚胎脊髓中心室神经祖细胞的少突胶质细胞祖细胞的初始生成。miRNA还调节少突胶质细胞发育的后期事件,包括细胞增殖、成熟和髓鞘形成。此外,miRNA对于星形胶质细胞的发育是必需的,并且抑制miRNA生成完全阻断脊髓中的星形胶质细胞生成。
Mounting evidence indicates that microRNAs (miRNAs) play important roles in the control of glial cell development in the central nervous system. Suppression of miRNA formation disrupts the initial generation of oligodendrocyte progenitor cells from the ventricular neuroprogenitor cells in the embryonic spinal cord. miRNAs also regulate the later events of oligodendrocyte development, including cell proliferation, maturation, and myelin formation. In addition, miRNAs are essential for the development of astrocytes, and inhibition of miRNA genesis completely blocks astrogliogenesis in the spinal cord.
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发表时间: 2010-07-01
期刊: DEVELOPMENT
影响因子: 4.6
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DOI: 10.1155/jbb/2006/69616
发表时间: 2006
影响因子: --
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DOI: 10.1016/j.devcel.2006.08.011
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Dicer1 和 miR-219 是正常少突胶质细胞分化和髓鞘形成所必需的。
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发表时间: 2010-03-11
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