Zebrafish as a model to understand autophagy and its role in neurological disease.
Zebrafish as a model to understand autophagy and its role in neurological disease.
复制标题
斑马鱼是一种了解自噬及其在神经疾病中的作用的模型。
DOI：
10.1016/j.bbadis.2011.01.004
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发表时间：
2011-04
影响因子：
6.2
通讯作者：
Rubinsztein, David C.
中科院分区：
文献类型：
--
作者：
Fleming, Angeleen;Rubinsztein, David C.
在过去的十年中，斑马鱼（Danio rerio）已成为脊椎动物发育研究的流行模型系统，因为该物种的胚胎和幼虫较小、透明且在子宫外快速发育，允许对胚胎发生和器官发生进行体内分析。对信号通路和疾病过程感兴趣的研究人员也可以利用这些特征，因此，关于使用斑马鱼来模拟人类疾病的文献越来越多。该模型对于探索自噬（一种进化上保守的蛋白质降解机制）如何影响一系列不同人类疾病的发病机制以及评估该途径作为潜在的治疗策略具有巨大的潜力。在这里，我们总结了关于真核细胞自噬调节及其在神经退行性疾病中的作用的已知信息，并强调了使用斑马鱼的研究如何帮助我们进一步了解这些过程。 ► 斑马鱼已成为研究脊椎动物发育的流行模型系统。 ► 关于使用斑马鱼模拟人类疾病的文献越来越多。 ► 该模型具有探索自噬如何影响疾病发病机制的潜力。 ► 本综述考虑了斑马鱼如何帮助进一步了解这些过程。
In the past decade, the zebrafish (Danio rerio) has become a popular model system for the study of vertebrate development, since the embryos and larvae of this species are small, transparent and undergo rapid development ex utero, allowing in vivo analysis of embryogenesis and organogenesis. These characteristics can also be exploited by researchers interested in signaling pathways and disease processes and, accordingly, there is a growing literature on the use of zebrafish to model human disease. This model holds great potential for exploring how autophagy, an evolutionarily conserved mechanism for protein degradation, influences the pathogeneses of a range of different human diseases and for the evaluation of this pathway as a potential therapeutic strategy. Here we summarize what is known about the regulation of autophagy in eukaryotic cells and its role in neurodegenerative disease and highlight how research using zebrafish has helped further our understanding of these processes. ► Zebrafish has become a popular model system for the study of vertebrate development. ► There is a growing literature on the use of zebrafish to model human disease. ► This model has potential for exploring how autophagy affects disease pathogenesis. ► This review considers how zebrafish may help further understanding of these processes.
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影响因子：
15.1
作者：
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通讯作者：
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Rubinsztein, David C.
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