Prognostic value and predictive threshold of tumor volume for patients with locally advanced nasopharyngeal carcinoma receiving intensity-modulated radiotherapy.
Prognostic value and predictive threshold of tumor volume for patients with locally advanced nasopharyngeal carcinoma receiving intensity-modulated radiotherapy.
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DOI：
10.1186/s40880-016-0159-2
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发表时间：
2016-11-16
影响因子：
--
通讯作者：
Shen LF
中科院分区：
文献类型：
--
作者：
He YX;Wang Y;Cao PF;Shen L;Zhao YJ;Zhang ZJ;Chen DM;Yang TB;Huang XQ;Qin Z;Dai YY;Shen LF
原发肿瘤靶区体积（GTV-P）对鼻咽癌（NPC）患者的预后预测具有重要意义，但对于局部晚期NPC患者调强放疗（IMRT）是否具有同样的意义尚不清楚。本研究旨在探讨肿瘤体积对局部晚期鼻咽癌调强放疗患者预后的预测价值，并寻找一个合适的GTV-P预后判断临界值。回顾性分析358例接受调强放射治疗的局部晚期鼻咽癌患者的临床资料。采用受试者工作特征（ROC）曲线确定GTV-P预测不同终点[总生存期（OS）、局部无复发生存期（LRFS）、无远处转移生存期（DMFS）和无病生存期（DFS）]的截断值，并与美国癌症联合委员会T分期系统进行比较，检验GTV-P的预后价值。358例局部晚期鼻咽癌患者根据GTV-P的临界值分为两组：GTV-P ≤46.4 mL组219例（61.2%），GTV-P > 46.4 mL组139例（38.8%）。GTV-P ≤ 46.4 mL患者的3年OS、LRFS、DMFS和DFS率均高于GTV-P > 46.4 mL患者（均P < 0.05）。多因素分析显示GTV-P >46.4 mL是影响患者生存的独立不良预后因素。ROC曲线验证GTV-P的预测能力明显优于T分类（P < 0.001），具有上级意义。预测OS、LRFS、DMFS和DFS的GTV-P临界值分别为46.4、57.9、75.4和46.4 mL。在局部晚期鼻咽癌患者中，GTV-P >46.4 mL是IMRT后生存的独立不良预后指标，其预后价值上级于T分类。
Gross target volume of primary tumor (GTV-P) is very important for the prognosis prediction of patients with nasopharyngeal carcinoma (NPC), but it is unknown whether the same is true for locally advanced NPC patients treated with intensity-modulated radiotherapy (IMRT). This study aimed to clarify the prognostic value of tumor volume for patient with locally advanced NPC receiving IMRT and to find a suitable cut-off value of GTV-P for prognosis prediction. Clinical data of 358 patients with locally advanced NPC who received IMRT were reviewed. Receiver operating characteristic (ROC) curves were used to identify the cut-off values of GTV-P for the prediction of different endpoints [overall survival (OS), local relapse-free survival (LRFS), distant metastasis-free survival (DMFS), and disease-free survival (DFS)] and to test the prognostic value of GTV-P when compared with that of the American Joint Committee on Cancer T staging system. The 358 patients with locally advanced NPC were divided into two groups by the cut-off value of GTV-P as determined using ROC curves: 219 (61.2%) patients with GTV-P ≤46.4 mL and 139 (38.8%) with GTV-P >46.4 mL. The 3-year OS, LRFS, DMFS, and DFS rates were all higher in patients with GTV-P ≤46.4 mL than in those with GTV-P > 46.4 mL (all P < 0.05). Multivariate analysis indicated that GTV-P >46.4 mL was an independent unfavorable prognostic factor for patient survival. The ROC curve verified that the predictive ability of GTV-P was superior to that of T category (P < 0.001). The cut-off values of GTV-P for the prediction of OS, LRFS, DMFS, and DFS were 46.4, 57.9, 75.4 and 46.4 mL, respectively. In patients with locally advanced NPC, GTV-P >46.4 mL is an independent unfavorable prognostic indicator for survival after IMRT, with a prognostic value superior to that of T category.
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影响因子：
8.8
作者：
Stanley, J A;Shipley, W U;Steel, G G
通讯作者：
Steel, G G
影响因子：
--
作者：
Wei KR;Zheng RS;Zhang SW;Liang ZH;Ou ZX;Chen WQ
通讯作者：
Chen WQ
DOI：
10.1002/hed.23010
发表时间：
2013-05-01
影响因子：
2.9
作者：
Wu, Zheng;Zeng, Rui-Fang;Huang, Shao-Min
通讯作者：
Huang, Shao-Min
原发肿瘤体积是否仍是鼻咽癌调强放射治疗的预后因素？
影响因子：
5.7
作者：
Guo, Rui;Sun, Ying;Ma, Jun
通讯作者：
Ma, Jun
DOI：
10.1186/1748-717x-8-87
发表时间：
2013-04-11
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Wu Z;Gu MF;Zeng RF;Su Y;Huang SM
通讯作者：
Huang SM