A Theoretical Framework for the Dynamics of Multiple Intrinsic Oscillators in Single Neurons
A Theoretical Framework for the Dynamics of Multiple Intrinsic Oscillators in Single Neurons
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单神经元中多个本征振荡器动力学的理论框架
DOI：
10.1007/978-1-4614-0739-3_3
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
B. Gutkin
中科院分区：
文献类型：
--
作者：
Michiel W. H. Remme;M. Lengyel;B. Gutkin
树突树对神经元在将其突触输入转换为动作电位输出时执行的基本计算有重要贡献。传统上，这些计算的特点是时间和空间本地化。在这种情况下，神经元计算从其当前输入到其当前输出的近瞬时映射，这是由在功能隔离的隔室中产生的树突贡献的体细胞总和引起的。然而，最近关于树突中存在振荡的证据表明了一种质的不同的操作模式：这种振荡的瞬时相位可以取决于长期的输入历史，并且在适当的条件下，即使是远程的树突振荡器也可以通过同步进行交互。在这里，我们开发了一个数学框架来分析局部树突振荡的相互作用，以及这些相互作用影响单细胞计算的方式。结合弱耦合振子方法和电缆理论的参数，我们推导出多个振荡树枝状隔间的锁相状态。我们表征了锁相特性如何取决于振荡枝晶的关键参数：（活性）枝晶段的电紧张特性，以及枝晶振荡器的固有特性。作为一个直接的后果，我们展示了如何输入到树突可以调制锁相行为，因此全球树突的连贯性。反过来，树突相干性能够门控突触信号到索马的整合和传播，最终导致体细胞锋电位产生的有效控制。我们的研究结果表明，树突振荡使树突树操作更多的全球时间和空间尺度比以前认为的，值得注意的是，当地的树突活动可能是一种机制，产生持续的全细胞电压振荡。
The dendritic tree contributes significantly to the elementary computations a neuron performs while converting its synaptic inputs into action potential output. Traditionally, these computations have been characterized as both temporally and spatially localized. Under this account, neurons compute near-instantaneous mappings from their current input to their current output, brought about by somatic summation of dendritic contributions that are generated in functionally segregated compartments. However, recent evidence about the presence of oscillations in dendrites suggests a qualitatively different mode of operation: the instantaneous phase of such oscillations can depend on a long history of inputs, and, under appropriate conditions, even dendritic oscillators that are remote may interact through synchronization. Here, we develop a mathematical framework to analyze the interactions of local dendritic oscillations, and the way these interactions influence single cell computations. Combining weakly coupled oscillator methods with cable theoretic arguments, we derive phase-locking states for multiple oscillating dendritic compartments. We characterize how the phase-locking properties depend on key parameters of the oscillating dendrite: the electrotonic properties of the (active) dendritic segment, and the intrinsic properties of the dendritic oscillators. As a direct consequence, we show how input to the dendrites can modulate phase-locking behavior and hence global dendritic coherence. In turn, dendritic coherence is able to gate the integration and propagation of synaptic signals to the soma, ultimately leading to an effective control of somatic spike generation. Our results suggest that dendritic oscillations enable the dendritic tree to operate on more global temporal and spatial scales than previously thought; notably that local dendritic activity may be a mechanism for generating on-going whole-cell voltage oscillations.
影响因子：
2.5
作者：
Motoharu Yoshida;A. Alonso
通讯作者：
Motoharu Yoshida;A. Alonso
影响因子：
5.5
作者：
LLINAS, R;SUGIMORI, M
通讯作者：
SUGIMORI, M