In vitro release kinetics of antituberculosis drugs from nanoparticles assessed using a modified dissolution apparatus.
In vitro release kinetics of antituberculosis drugs from nanoparticles assessed using a modified dissolution apparatus.
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DOI：
10.1155/2013/136590
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发表时间：
2013
影响因子：
--
通讯作者：
Löbenberg R
中科院分区：
文献类型：
--
作者：
Gao Y;Zuo J;Bou-Chacra N;Pinto Tde J;Clas SD;Walker RB;Löbenberg R
本研究的目的是评估抗结核药物负载纳米颗粒（NPs）的体外释放动力学，使用“改进”的圆柱形装置，将再生纤维素膜与标准溶解装置连接（改进的圆柱形方法）。模型药物为利福平（RIF）和盐酸莫西沙星（MX）。分别对明胶和聚氰丙烯酸丁酯（PBCA） NPs作为纳米载体进行了评价。采用改良柱体法，以透析袋技术为对照，研究了载药NPs在不同介质中的溶出和释放动力学。结果表明，使用改进的圆柱体方法，所研究的纳米载体体系具有不同的释放曲线和独特的释放机制。改进的圆柱体方法还允许区分在存在或不存在酶降解的情况下，模型药物从明胶NPs中强制和正常的体外释放。在这些病例中，透析袋技术的使用导致无法区分NPs的药物释放机制。该方法为研究NPs中RIF和MX的体外释放提供了有效的工具，进一步表明该技术可用于纳米级载体系统的性能测试。
The aim of this study was to assess the in vitro release kinetics of antituberculosis drug-loaded nanoparticles (NPs) using a “modified” cylindrical apparatus fitted with a regenerated cellulose membrane attached to a standard dissolution apparatus (modifiedcylinder method). The model drugs that were used were rifampicin (RIF) and moxifloxacin hydrochloride (MX). Gelatin and polybutyl cyanoacrylate (PBCA) NPs were evaluated as the nanocarriers, respectively. The dissolution and release kinetics of the drugs from loaded NPs were studied in different media using the modified cylinder method and dialysis bag technique was used as the control technique. The results showed that use of the modified cylinder method resulted in different release profiles associated with unique release mechanisms for the nanocarrier systems investigated. The modified cylinder method also permitted discrimination between forced and normal in vitro release of the model drugs from gelatin NPs in the presence or absence of enzymatic degradation. The use of dialysis bag technique resulted in an inability to differentiate between the mechanisms of drug release from the NPs in these cases. This approach offers an effective tool to investigate in vitro release of RIF and MX from NPs, which further indicate that this technique can be used for performance testing of nanosized carrier systems.
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影响因子：
4.5
作者：
Zhang, Yong;Huo, Meirong;Xie, Shaofei
通讯作者：
Xie, Shaofei
影响因子：
3.4
作者：
Abdel-Mottaleb, Mona M. A.;Lamprecht, Alf
通讯作者：
Lamprecht, Alf
影响因子：
3
作者：
Bajpai, A. K.;Choubey, Jyoti
通讯作者：
Choubey, Jyoti
影响因子：
1.7
作者：
Kamat, BP;Seetharamappa, J
通讯作者：
Seetharamappa, J
DOI：
10.1016/j.ejpb.2010.05.002
发表时间：
2010-09-01
影响因子：
4.9
作者：
Al-Hallak, Kamal M. H. D.;Azarmi, Shirzad;Loebenberg, Raimar
通讯作者：
Loebenberg, Raimar