SUMOylation Wrestles With the Occurrence and Development of Breast Cancer.
SUMOylation Wrestles With the Occurrence and Development of Breast Cancer.
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SUMOylation 与乳腺癌的发生和发展作斗争
DOI：
10.3389/fonc.2021.659661
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发表时间：
2021
影响因子：
4.7
通讯作者：
Wu H
中科院分区：
文献类型：
--
作者：
Qin Y;Yuan H;Chen X;Yang X;Xing Z;Shen Y;Dong W;An S;Qi Y;Wu H
乳腺癌是癌症中发病率最高的疾病，也是全球女性最常见的死亡原因。乳腺癌发病机制的详细机制尚未完全阐明，目前仍缺乏有效的治疗方法。 SUMO化共价结合大量细胞蛋白，影响其细胞定位和生物活性，参与众多细胞过程。 SUMO化是一个重要的过程，SUMO化的不平衡会导致人类疾病的进展。越来越多的证据表明大量SUMO化蛋白参与乳腺癌的发生和发展。本文综述了近年来乳腺癌蛋白SUMO化的一系列研究。 SUMO化蛋白的研究提供了对乳腺癌病理生理学的全面了解，并为乳腺癌的治疗提供了不断发展的治疗策略。
Breast cancer has the highest incidence among cancers and is the most frequent cause of death in women worldwide. The detailed mechanism of the pathogenesis of breast cancer has not been fully elucidated, and there remains a lack of effective treatment methods for the disease. SUMOylation covalently conjugates a large amount of cellular proteins, and affects their cellular localization and biological activity to participate in numerous cellular processes. SUMOylation is an important process and imbalance of SUMOylation results in the progression of human diseases. Increasing evidence shows that numerous SUMOylated proteins are involved in the occurrence and development of breast cancer. This review summarizes a series of studies on protein SUMOylation in breast cancer in recent years. The study of SUMOylated proteins provides a comprehensive understanding of the pathophysiology of breast cancer and provides evolving therapeutic strategies for the treatment of breast cancer.
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影响因子：
--
作者：
Cashman R;Cohen H;Ben-Hamo R;Zilberberg A;Efroni S
通讯作者：
Efroni S
α-连环蛋白 SUMO 化可增加 I kappa B α 稳定性并抑制乳腺癌进展
影响因子：
6.2
作者：
Chen H;Xu Z;Li X;Yang Y;Li B;Li Y;Xia K;Wang J;Li S;Wang M;Wu H
通讯作者：
Wu H
影响因子：
--
作者：
Chandhoke AS;Chanda A;Karve K;Deng L;Bonni S
通讯作者：
Bonni S
影响因子：
8
作者：
Chen, R-S;Song, Y-M;Li, W.
通讯作者：
Li, W.
DOI：
10.1126/science.1254211
发表时间：
2014-10-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Buckley CD;Tan J;Anderson KL;Hanein D;Volkmann N;Weis WI;Nelson WJ;Dunn AR
通讯作者：
Dunn AR