BPIFB1 promotes metastasis of hormone receptor-positive breast cancer via inducing macrophage M2-like polarization.
BPIFB1 promotes metastasis of hormone receptor-positive breast cancer via inducing macrophage M2-like polarization.
复制标题
BPIFB1通过诱导巨噬细胞m2样极化促进激素受体阳性乳腺癌的转移。
作者：
转移是影响激素受体阳性乳腺癌（BC）预后的重要因素。然而，肿瘤细胞迁移和侵袭的分子基础仍然知之甚少。在这里，我们发现在先天免疫中起重要作用的含有杀菌/通透性增加-折叠的B家族成员1 （BPIFB1）在乳腺癌中显著升高，并与淋巴结转移相关。BPIFB1及其编码mRNA的高表达与激素受体阳性BC的不良预后显著相关。通过富集分析和构建免疫浸润评价，我们预测了BPIFB1促进巨噬细胞M2极化的潜在能力。最后，我们通过建立BC肿瘤细胞/THP1共培养系统、qPCR、Transwell实验和动物实验，证明BPIFB1通过刺激巨噬细胞的M2样极化促进激素受体阳性BC的转移。据我们所知，这是关于BPIFB1在激素受体阳性乳腺癌中通过激活巨噬细胞M2极化作为肿瘤启动子作用的第一篇报道。总之，这些结果为BPIFB1在BC中的作用机制提供了新的见解。BPIFB1在促进巨噬细胞M2极化中起关键作用，从而增强激素受体阳性乳腺癌细胞的转移能力。
Metastasis is an important factor affecting the prognosis of hormone receptor‐positive breast cancer (BC). However, the molecular basis for migration and invasion of tumor cells remains poorly understood. Here, we identify that bactericidal/permeability‐increasing‐fold‐containing family B member 1 (BPIFB1), which plays an important role in innate immunity, is significantly elevated in breast cancer and associated with lymph node metastasis. High expression of BPIFB1 and its coding mRNA are significantly associated with poor prognosis of hormone receptor‐positive BC. Using enrichment analysis and constructing immune infiltration evaluation, we predict the potential ability of BPIFB1 to promote macrophage M2 polarization. Finally, we demonstrate that BPIFB1 promotes the metastasis of hormone receptor‐positive BC by stimulating the M2‐like polarization of macrophages via the establishment of BC tumor cells/THP1 co‐culture system, qPCR, Transwell assay, and animal experiments. To our knowledge, this is the first report on the role of BPIFB1 as a tumor promoter by activating the macrophage M2 polarization in hormone receptor‐positive breast carcinoma. Together, these results provide novel insights into the mechanism of BPIFB1 in BC. BPIFB1 plays a pivotal role in promoting macrophage M2 polarization, which enhances the ability of hormone receptor‐positive breast cancer cells to metastasize.
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DOI：
10.1038/nrclinonc.2016.217
发表时间：
2017-07
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
Mantovani A;Marchesi F;Malesci A;Laghi L;Allavena P
通讯作者：
Allavena P
影响因子：
3.1
作者：
Hayes, Edd;Nicholson, Robert I.;Hiscox, Stephen
通讯作者：
Hiscox, Stephen
影响因子：
9.8
作者：
Jin, Guangfu;Zhu, Meng;Shen, Hongbing
通讯作者：
Shen, Hongbing
DOI：
10.1126/science.aay9189
发表时间：
2020-05-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Nejman D;Livyatan I;Fuks G;Gavert N;Zwang Y;Geller LT;Rotter-Maskowitz A;Weiser R;Mallel G;Gigi E;Meltser A;Douglas GM;Kamer I;Gopalakrishnan V;Dadosh T;Levin-Zaidman S;Avnet S;Atlan T;Cooper ZA;Arora R;Cogdill AP;Khan MAW;Ologun G;Bussi Y;Weinberger A;Lotan-Pompan M;Golani O;Perry G;Rokah M;Bahar-Shany K;Rozeman EA;Blank CU;Ronai A;Shaoul R;Amit A;Dorfman T;Kremer R;Cohen ZR;Harnof S;Siegal T;Yehuda-Shnaidman E;Gal-Yam EN;Shapira H;Baldini N;Langille MGI;Ben-Nun A;Kaufman B;Nissan A;Golan T;Dadiani M;Levanon K;Bar J;Yust-Katz S;Barshack I;Peeper DS;Raz DJ;Segal E;Wargo JA;Sandbank J;Shental N;Straussman R
通讯作者：
Straussman R
利用基因本体和KEGG通路的富集来预测和分析必需基因
影响因子：
3.7
作者：
Chen L;Zhang YH;Wang S;Zhang Y;Huang T;Cai YD
通讯作者：
Cai YD