The human tumor microbiome is composed of tumor type-specific intracellular bacteria.
The human tumor microbiome is composed of tumor type-specific intracellular bacteria.
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DOI：
10.1126/science.aay9189
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发表时间：
2020-05-29
期刊：
影响因子：
--
通讯作者：
Straussman R
中科院分区：
文献类型：
--
作者：
Nejman D;Livyatan I;Fuks G;Gavert N;Zwang Y;Geller LT;Rotter-Maskowitz A;Weiser R;Mallel G;Gigi E;Meltser A;Douglas GM;Kamer I;Gopalakrishnan V;Dadosh T;Levin-Zaidman S;Avnet S;Atlan T;Cooper ZA;Arora R;Cogdill AP;Khan MAW;Ologun G;Bussi Y;Weinberger A;Lotan-Pompan M;Golani O;Perry G;Rokah M;Bahar-Shany K;Rozeman EA;Blank CU;Ronai A;Shaoul R;Amit A;Dorfman T;Kremer R;Cohen ZR;Harnof S;Siegal T;Yehuda-Shnaidman E;Gal-Yam EN;Shapira H;Baldini N;Langille MGI;Ben-Nun A;Kaufman B;Nissan A;Golan T;Dadiani M;Levanon K;Bar J;Yust-Katz S;Barshack I;Peeper DS;Raz DJ;Segal E;Wargo JA;Sandbank J;Shental N;Straussman R
100多年前，细菌首次在人类肿瘤中被发现，但由于其生物量低，肿瘤微生物组的表征仍然具有挑战性。我们对肿瘤微生物组进行了全面分析，研究了7种癌症类型的1526个肿瘤及其邻近正常组织，包括乳腺癌，肺癌，卵巢癌，胰腺癌，黑色素瘤，骨肿瘤和脑肿瘤。我们发现，每种肿瘤类型都有不同的微生物组组成，乳腺癌具有特别丰富和多样的微生物组。肿瘤内的细菌主要是细胞内的，并且存在于癌细胞和免疫细胞中。我们还注意到肿瘤内细菌或其预测功能与肿瘤类型和亚型、患者吸烟状况以及对免疫治疗的反应之间的相关性。
Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients' smoking status, and the response to immunotherapy.
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结合16S rRNA基因变量区域可以实现高分辨率微生物社区分析。
影响因子：
15.5
作者：
Fuks G;Elgart M;Amir A;Zeisel A;Turnbaugh PJ;Soen Y;Shental N
通讯作者：
Shental N
影响因子：
4.6
作者：
Bankhead P;Loughrey MB;Fernández JA;Dombrowski Y;McArt DG;Dunne PD;McQuaid S;Gray RT;Murray LJ;Coleman HG;James JA;Salto-Tellez M;Hamilton PW
通讯作者：
Hamilton PW
影响因子：
3.7
作者：
Du J;Zhou N;Liu H;Jiang F;Wang Y;Hu C;Qi H;Zhong C;Wang X;Li Z
通讯作者：
Li Z
影响因子：
15.5
作者：
Davis, Nicole M;Proctor, Diana M;Callahan, Benjamin J
通讯作者：
Callahan, Benjamin J
影响因子：
7
作者：
Castellarin, Mauro;Warren, Rene L.;Holt, Robert A.
通讯作者：
Holt, Robert A.