Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome.
Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome.
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DOI：
10.1016/j.bbalip.2014.08.006
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Chiang N
中科院分区：
文献类型：
--
作者：
Serhan CN;Dalli J;Colas RA;Winkler JW;Chiang N
急性炎症反应是保护性的，但如果不及时解决，可能导致慢性炎症和器官纤维化。研究小鼠自限性（自消退）炎性渗出物的系统方法和结构解析揭示了体内刺激炎症内源性消退机制的新型消退相介质。解决炎症渗出物和人类白细胞利用DHA和其他n-3 EFA产生三个结构不同的家庭的有效的二和三羟基的产品，在每个家庭中有几个立体特异性的有效介质。考虑到它们的强效和立体选择性皮克作用，这些来自DHA代谢组的介质新家族的特定成员被命名为D系列消退素（Resolvin D1至Resolvin D 6），保护素（包括保护素D1-神经保护素D1）和maresins（MaR 1和MaR 2）。在这篇综述中，我们集中在a）生物合成的protectin和maresins作为抗炎促解决调解人; B）他们的完整的立体化学分配和行动在体内疾病模型。每种途径都涉及含环氧化物中间体的生物合成，这些中间体是由人白细胞和渗出液中的含过氧化氢前体产生的。此外，阿司匹林触发内源性DHA代谢组，其在炎性渗出物和人白细胞中生物合成有效产物，即阿司匹林触发的神经保护素D1/保护素D1 [AT-（NPD 1/PD 1）]。这些新的生物活性介质家族的鉴定和结构解析已经开启了在几个过程中多种病理生理作用的可能性，包括感染、炎性疼痛、组织再生、神经保护-神经退行性疾病、伤口愈合等。
Acute inflammatory responses are protective, yet without timely resolution can lead to chronic inflammation and organ fibrosis. A systems approach to investigate self-limited (self-resolving) inflammatory exudates in mice and structural elucidation uncovered novel resolution phase mediators in vivo that stimulate endogenous resolution mechanisms in inflammation. Resolving inflammatory exudates and human leukocytes utilize DHA and other n-3 EFA to produce three structurally distinct families of potent di- and trihydroxy-containing products, with several stereospecific potent mediators in each family. Given their potent and stereoselective picogram actions, specific members of these new families of mediators from the DHA metabolome were named D-series resolvins (Resolvin D1 to Resolvin D6), protectins (including protectin D1-neuroprotectin D1), and maresins (MaR1 and MaR2). In this review, we focus on a) biosynthesis of protectins and maresins as anti-inflammatory - pro-resolving mediators; b) their complete stereochemical assignments and actions in vivo in disease models. Each pathway involves the biosynthesis of epoxide-containing intermediates produced from hydroperoxy-containing precursors from human leukocytes and within exudates. Also, aspirin triggers an endogenous DHA metabolome that biosynthesizes potent products in inflammatory exudates and human leukocytes, namely aspirin-triggered Neuroprotectin D1/Protectin D1 [AT-(NPD1/PD1)]. Identification and structural elucidation of these new families of bioactive mediators in resolution has opened the possibility of diverse pathophysiologic actions in several processes including infection, inflammatory pain, tissue regeneration, neuroprotection-neurodegenerative disorders, wound healing, and others.
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影响因子：
64.8
作者：
Chiang, Nan;Fredman, Gabrielle;Backhed, Fredrik;Oh, Sungwhan F.;Vickery, Thad;Schmidt, Birgitta A.;Serhan, Charles N.
通讯作者：
Serhan, Charles N.
DOI：
10.1073/pnas.0405445101
发表时间：
2004-10-19
影响因子：
11.1
作者：
Chiang, N;Bermudez, EA;Serhan, CN
通讯作者：
Serhan, CN
DOI：
10.1016/0006-291x(84)90601-6
发表时间：
1984-01-01
影响因子：
3.1
作者：
BAZAN, NG;BIRKLE, DL;REDDY, TS
通讯作者：
REDDY, TS
影响因子：
4.8
作者：
Chen, Ping;Vericel, Evelyne;Guichardant, Michel
通讯作者：
Guichardant, Michel
影响因子：
4.8
作者：
Biteman, Benjamin;Hassan, Iram R.;Gronert, Karsten
通讯作者：
Gronert, Karsten