Emerging role of Notch in stem cells and cancer.

Emerging role of Notch in stem cells and cancer.
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Notch在干细胞和癌症中的新兴作用。

DOI:
10.1016/j.canlet.2008.09.030
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发表时间:
2009-06-28
期刊:
影响因子:
9.7
通讯作者:
Sarkar, Fazlul H.
Sarkar, Fazlul H.
中科院分区:
医学1区
文献类型:
--
作者:
Wang, Zhiwei;Li, Yiwei;Banerjee, Sanjeev;Sarkar, Fazlul H.

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The Notch signaling pathway is known to be responsible for maintaining a balance between cell proliferation and death and, as such, plays important roles in the formation of many types of human tumors. Recently, Notch signaling pathway has been shown to control stem cell self renewal and multi-potency. As many cancers are thought to be developed from a number of cancer stem-like cells, which are also known to be linked with the acquisition of epithelial-mesenchymal transition (EMT); and thus suggesting an expanding role of Notch signaling in human tumor progression.
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