Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans.
Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans.
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DOI：
10.1016/j.cub.2017.03.028
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发表时间：
2017-05-08
期刊：
影响因子：
--
通讯作者：
Kahana MJ
中科院分区：
文献类型：
--
作者：
Ezzyat Y;Kragel JE;Burke JF;Levy DF;Lyalenko A;Wanda P;O'Sullivan L;Hurley KB;Busygin S;Pedisich I;Sperling MR;Worrell GA;Kucewicz MT;Davis KA;Lucas TH;Inman CS;Lega BC;Jobst BC;Sheth SA;Zaghloul K;Jutras MJ;Stein JM;Das SR;Gorniak R;Rizzuto DS;Kahana MJ
人们常常忘记信息，因为他们没有有效地对信息进行编码。在这里，我们验证了有针对性的电刺激可以调节神经编码状态和随后的记忆结果的假设。利用脑内植入电极的神经外科癫痫患者的记录，我们训练了多元分类器来区分学习期间预测记忆和遗忘的频谱活动，然后在学习期间施加刺激的后续会话中解码神经活动。当分类器显示编码效率低时，刺激会增加编码状态估计和召回率，而当分类器显示编码效率高时，刺激会产生相反的效果。刺激产生的较高的编码状态估计与更多的神经活动与上下文记忆编码相关的证据有关。在确定刺激调节记忆的条件下，数据提出了治疗记忆功能障碍的策略。直接脑刺激是一种很有前途的调节认知功能的工具。Ezzyat等人表明，刺激对情景记忆编码的不同影响取决于其相对于大脑编码状态的时间。这些数据建议应用于记忆功能障碍的闭环治疗。
People often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting, then decoded neural activity in later sessions in which we applied stimulation during learning. Stimulation increased encoding-state estimates and recall if delivered when the classifier indicated low encoding efficiency but had the reverse effect if stimulation was delivered when the classifier indicated high encoding efficiency. Higher encoding-state estimates from stimulation were associated with greater evidence of neural activity linked to contextual memory encoding. In identifying the conditions under which stimulation modulates memory, the data suggest strategies for therapeutically treating memory dysfunction. Direct brain stimulation is a promising tool for modulating cognitive function. Ezzyat et al. show that stimulation differentially affects episodic memory encoding depending on its timing relative to the brain’s encoding state. The data suggest applications for closed-loop treatment of memory dysfunction.
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影响因子：
--
作者：
Bronstein JM;Tagliati M;Alterman RL;Lozano AM;Volkmann J;Stefani A;Horak FB;Okun MS;Foote KD;Krack P;Pahwa R;Henderson JM;Hariz MI;Bakay RA;Rezai A;Marks WJ Jr;Moro E;Vitek JL;Weaver FM;Gross RE;DeLong MR
通讯作者：
DeLong MR
DOI：
10.1073/pnas.1405003111
发表时间：
2014-10-14
影响因子：
11.1
作者：
Fox, Michael D.;Buckner, Randy L.;Pascual-Leone, Alvaro
通讯作者：
Pascual-Leone, Alvaro
影响因子：
25
作者：
deBettencourt MT;Cohen JD;Lee RF;Norman KA;Turk-Browne NB
通讯作者：
Turk-Browne NB
影响因子：
4.1
作者：
HAGLUND, MM;OJEMANN, GA;BLASDEL, GG
通讯作者：
BLASDEL, GG
影响因子：
5.7
作者：
Kim, Hongkeun
通讯作者：
Kim, Hongkeun