Effects of Nori- and Wakame-enriched meats with or without supplementary cholesterol on arylesterase activity, lipaemia and lipoproteinaemia in growing Wistar rats
Effects of Nori- and Wakame-enriched meats with or without supplementary cholesterol on arylesterase activity, lipaemia and lipoproteinaemia in growing Wistar rats
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富含海苔和裙带菜的肉类（添加或不添加胆固醇）对生长 Wistar 大鼠芳基酯酶活性、血脂和脂蛋白血症的影响
DOI：
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发表时间：
2011
影响因子：
3.6
通讯作者：
F. Sánchez
中科院分区：
文献类型：
--
作者：
Raúl Olivero;A. Schultz;Miguel Vázquez;L. González;S. Bastida;J. Benedí;M. Sánchez;M. González;F. Sánchez
有些海藻具有抗氧化和降低胆固醇的特性。研究了在重组肉中添加裙带菜和紫菜对脂肪酯酶活性和脂蛋白浓度及组成的影响。在本研究中，6组10只雄性生长期Wistar大鼠分别饲喂85% AIN-93 M饲料和15%冻干RM的混合物35 d。对照组（C）食用对照RM，W和N组分别食用含5%W和5%N的RM。高胆固醇C（CC）、W（CW）和N（CN）组在相应的基础日粮中添加胆固醇（2.43%）和胆酸（0.49%）。饲料中的胆固醇诱导较低的生长率（P <0.001）。W和N日粮均显著提高AE活性。VLDL-胆固醇值在N大鼠中低于W大鼠。CC组和CW组大鼠脑内AE活性均显著高于对照组（P <0.001），CN组无明显变化。CN组AE低于CC组和CW组（P <0.05）。与CC大鼠相比，CN饮食部分阻断了CC和CW饮食中观察到的高胆固醇血症诱导（P <0.001），并降低了TAG水平（至少P <0.05）。尽管饮食胆固醇补充剂增加了所有大鼠的总胆固醇、VLDL-胆固醇和（中密度脂蛋白+LDL）-胆固醇（均P <0.001），但CN饮食适度改善了高胆固醇血症大鼠的脂蛋白谱。CN大鼠AE活性和血浆胆固醇的变化，但在CW大鼠中没有表明这两个参数之间可能存在关系。它的结论是，列入RM富含N可用于高胆固醇血症的饮食，以改善脂蛋白代谢。
Some seaweeds exert antioxidant and hypocholesterolaemic properties. The effects of diets including restructured meats (RM) containing Wakame (W) or Nori (N) algae on arylesterase (AE) activity and lipoprotein concentration and composition were tested. In the present study, six groups of ten male growing Wistar rats each were fed a mix of 85 % AIN-93M diet and 15 % freeze-dried RM for 35 d. The control group (C) consumed control RM, the W and N groups consumed RM with 5 % W and 5 % N, respectively. The cholesterol-enriched C (CC), W (CW) and N (CN) groups consumed their corresponding basal diets with supplementary cholesterol (2·43 %) and cholic acid (0·49 %). Cholesterol in the diet induced lower (P < 0·001) growth ratios. Both W and N diets significantly increased AE activity. VLDL-cholesterol values were lower in N rats than in W rats. AE activity increased (P < 0·001) in CC and CW rats but not in CN rats compared with their corresponding counterparts. AE was lower (P < 0·05) in the CN group than in the CC and CW groups. The CN diet partially blocked (P < 0·001) the hypercholesterolaemic induction observed in CC and CW diets and reduced TAG levels (at least P < 0·05) with respect to those of CC rats. Although dietary cholesterol supplementation increased total cholesterol, VLDL-cholesterol and (intermediate-density lipoprotein+LDL)-cholesterol (all P < 0·001) in all rats, the CN diet moderately improved the lipoprotein profile of hypercholesterolaemic rats. Changes in AE activity and plasma cholesterol in CN rats but not in CW rats suggest a possible relationship between the two parameters. It is concluded that inclusion of RM enriched with N may be used in hypercholesterolaemic diets to improve lipoprotein metabolism.
DOI：
10.1056/nejm199906173402418
发表时间：
1999-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Williams Kj;I. Tabas
通讯作者：
Williams Kj;I. Tabas
影响因子：
6.5
作者：
R. Havel
通讯作者：
R. Havel