Intrinsic and extrinsic regulators of oligodendrocyte progenitor proliferation and differentiation.
Intrinsic and extrinsic regulators of oligodendrocyte progenitor proliferation and differentiation.
复制标题
少突胶质细胞祖细胞增殖和分化的内在和外在调节因子。
DOI：
10.1016/j.semcdb.2020.10.002
复制
发表时间：
2021-08
影响因子：
7.3
通讯作者：
Macklin, Wendy B.
中科院分区：
文献类型：
--
作者：
Adams, Katrina L.;Dahl, Kristin D.;Gallo, Vittorio;Macklin, Wendy B.
Oligodendrocytes are highly specialized glial cells, responsible for producing myelin in the central nervous system (CNS). The multi-stage process of oligodendrocyte development is tightly regulated to ensure proper lineage progression of oligodendrocyte progenitor cells (OPCs) to mature myelin producing oligodendrocytes. This developmental process involves complex interactions between several intrinsic signaling pathways that are modulated by an array of extrinsic factors. Understanding these regulatory processes is of crucial importance, as it may help to identify specific molecular targets both to enhance plasticity in the normal CNS and to promote endogenous recovery following injury or disease. This review describes two major regulators that play important functional roles in distinct phases of oligodendrocyte development: OPC proliferation and differentiation. Specifically, we highlight the roles of the extracellular astrocyte/radial glia-derived protein Endothelin-1 in OPC proliferation and the intracellular Akt/mTOR pathway in OPC differentiation. Lastly, we reflect on how recent advances in neuroscience and scientific technology will enable greater understanding into how intrinsic and extrinsic regulators interact to generate oligodendrocyte diversity.
登录
查看更多内容
影响因子：
16.2
作者：
Brinkmann, Bastian G.;Agarwal, Amit;Sereda, Michael W.;Garratt, Alistair N.;Mueller, Thomas;Wende, Hagen;Stassart, Ruth M.;Nawaz, Schanila;Humml, Christian;Velanac, Viktorija;Radyushkin, Konstantin;Goebbels, Sandra;Fischer, Tobias M.;Franklin, Robin J.;Lai, Cary;Ehrenreich, Hannelore;Birchmeier, Carmen;Schwab, Markus H.;Nave, Klaus Armin
通讯作者：
Nave, Klaus Armin
影响因子：
16.2
作者：
Canoll, PD;Musacchio, JM;Salzer, JL
通讯作者：
Salzer, JL
影响因子：
16.6
作者：
Adams, Katrina L.;Riparini, Giulia;Gallo, Vittorio
通讯作者：
Gallo, Vittorio
影响因子：
5.3
作者：
Bercury, Kathryn K.;Dai, JinXiang;Macklin, Wendy B.
通讯作者：
Macklin, Wendy B.
影响因子：
3.5
作者：
Baron, W;Metz, B;de Vries, H
通讯作者：
de Vries, H