Regulation of cell apoptosis by insulin-like growth factor I.
Regulation of cell apoptosis by insulin-like growth factor I.
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胰岛素样生长因子 I 调节细胞凋亡。
DOI：
10.1007/978-1-4615-1371-1_9
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发表时间：
2001
影响因子：
--
通讯作者：
Abdel-Fattah,G
中科院分区：
文献类型：
--
作者：
Hadsell,DL;Abdel-Fattah,G
Correct temporal and spatial regulation of apoptosis is critical for normal mammary gland development and lactation. Previous work with a strain of trans-genic mice that overexpress des(1-3)hIGF-I during pregnancy and lactation suggested that this growth factor inhibits apoptosis. The hypothesis tested within these studies is that overexpression of des(1-3)hIGF-I within the mammary gland inhibits apoptosis and the expression of apoptosis-associated genes that are known to be activated by the transcription factor AP-1. This inhibition of apoptosis was further posited to predispose the tissue to carcinogenesis. TUNEL analysis of mammary tissue from transgenic mice that overexpress des(1-3)hIGF-I under control of the rat whey acidic protein promoter showed only 25% (P < 0.05) of the number of apoptotic cells found in nontransgenic mice at the same stage of lactation. Northern analysis of RNA from these animals showed a 75% (P = 0.08) reduction in c-Jun mRNA abundance. Histological analysis of mammary tissue from nonlactating multiparous WAP-DES mice ranging in age from 13 to 25 months showed a variety of hyper-plastic lesions. These lesions aberrantly expressed the transgene. At 23 months of age 50% of the transgenic mice within this study developed adenocarcinomas. These results support the conclusion that inhibition of apoptosis within the mammary gland by IGF-I involves decreased activity of AP-1 and predisposes the tissue to tumors.
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注射卵巢激素和胰岛素的垂体切除大鼠的乳腺生长。
DOI：
--
发表时间：
1956
期刊：
Acta Physiologica Scandinavica
影响因子：
--
作者：
K. Ahrén;D. Jacobsohn
通讯作者：
D. Jacobsohn
影响因子：
56.9
作者：
L. Peso;M. González‐García;C. Page;R. Herrera;G. Núñez
通讯作者：
L. Peso;M. González‐García;C. Page;R. Herrera;G. Núñez
影响因子：
56.9
作者：
XIA, ZG;DICKENS, M;GREENBERG, ME
通讯作者：
GREENBERG, ME
影响因子：
11.2
作者：
Kevin J. Cullen;Douglas Yee;William S. Sly;James F. Perdue;Brian Hampton;Marc E. Lippman;N. Rosen
通讯作者：
Kevin J. Cullen;Douglas Yee;William S. Sly;James F. Perdue;Brian Hampton;Marc E. Lippman;N. Rosen
胰岛素受体底物1的转化潜力。
DOI：
--
发表时间：
1995
期刊：
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
影响因子：
--
作者：
D'Ambrosio,C;Keller,SR;Morrione,A;Lienhard,GE;Baserga,R;Surmacz,E
通讯作者：
Surmacz,E