Exploitation of evolutionarily conserved amoeba and mammalian processes by Legionella.
Exploitation of evolutionarily conserved amoeba and mammalian processes by Legionella.
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DOI：
10.1016/j.tim.2012.03.005
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发表时间：
2012-06
影响因子：
15.9
通讯作者：
Abu Kwaik, Yousef
中科院分区：
文献类型：
--
作者：
Al-Quadan, Tasneem;Price, Christopher T.;Abu Kwaik, Yousef
嗜肺军团菌在各种原生生物和后生动物细胞内增殖，通过细胞器运输/细胞内增殖(Dot/ICM)型IVB转位系统的缺陷将约300个效应器注入宿主细胞。原生生物基因的跨王国水平转移及其随后的收敛进化成为易位效应者，可能使嗜肺乳杆菌能够通过利用进化上的真核过程，如内质网到高尔基囊泡的运输、磷肌醇代谢、AMP化、去AMP化、戊烯基化、多泛素化、蛋白酶体降解和胞内氨基和寡肽酶，来适应各种原生生物和后生动物细胞内的生活。Ankyrin B(AnkB)F-box效应器利用多种保守的真核生物机制产生高水平的游离氨基酸，作为原生动物和后生动物细胞内增殖所必需的碳源和能量来源，以及哺乳动物肺部疾病的表现。
Legionella pneumophila proliferates within various protists and metazoan cells, where a cadre of ~300 effectors is injected into the host cell by the defect in organelle trafficking/intracellular multiplication (Dot/Icm) type IVB translocation system. Interkingdom horizontal gene transfer of genes of protists and their subsequent convergent evolution to become translocated effectors has probably enabled L. pneumophila to adapt to the intracellular life within various protists and metazoan cells through exploitation of evolutionarily eukaryotic processes, such as endoplasmic reticulum-to-Golgi vesicle traffic, phosphoinositol metabolism, AMPylation, deAMPylation, prenylation, polyubiquitination, proteasomal degradation and cytosolic amino- and oligo-peptidases. This is highlighted by the ankyrin B (AnkB) F-box effector that exploits multiple conserved eukaryotic machineries to generate high levels of free amino acids as sources of carbon and energy essential for intracellular proliferation in protists and metazoan cells and for manifestation of pulmonary disease in mammals.
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影响因子：
15.9
作者：
Al-Khodor S;Price CT;Kalia A;Abu Kwaik Y
通讯作者：
Abu Kwaik Y
影响因子：
6.7
作者：
Angot, Aurelie;Vergunst, Annette;Genin, Stephane;Peeters, Nemo
通讯作者：
Peeters, Nemo
影响因子：
30.3
作者：
Arasaki K;Toomre DK;Roy CR
通讯作者：
Roy CR
DOI：
10.1073/pnas.0907200106
发表时间：
2009-08-18
影响因子：
11.1
作者：
Ge, Jianning;Xu, Hao;Shao, Feng
通讯作者：
Shao, Feng
影响因子：
3.1
作者：
Hervet, Eva;Charpentier, Xavier;Doublet, Patricia
通讯作者：
Doublet, Patricia