Insulin-like growth factor binding protein 7 (IGFBP7), a link between heart failure and senescence.
Insulin-like growth factor binding protein 7 (IGFBP7), a link between heart failure and senescence.
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DOI：
10.1002/ehf2.14120
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发表时间：
2022-12
影响因子：
3.8
通讯作者：
de Boer, Rudolf A.
中科院分区：
文献类型：
--
作者：
Bracun, Valentina;van Essen, Bart;Voors, Adriaan A.;van Veldhuisen, Dirk J.;Dickstein, Kenneth;Zannad, Faiez;Metra, Marco;Anker, Stefan;Samani, Nilesh J.;Ponikowski, Piotr;Filippatos, Gerasimos;Cleland, John G. F.;Lang, Chim C.;Ng, Leong L.;Shi, Canxia;de Wit, Sanne;Msallem, Joseph P. About;Meijers, Wouter C.;Klip, IJsbrand T.;van der Meer, Peter;de Boer, Rudolf A.
胰岛素类似生长因子结合蛋白7（IGFBP7）是心力衰竭患者（HF）的感应分泌组的标志，我们评估了心力衰竭患者IGFBP7的预后价值。与血浆IGFBP7浓度升高有关。
我们已经在2250名患有新的或令人担忧的心力衰竭的受试者中测量了血浆IGFBP7浓度（Biostat -CHF队列）。 ，在HF住院数量较高的受试者中。生物标志物，包括较高的NT -ProBNP，HSTNT和尿素水平。 1.75，95％CI 1.25–2.46; IGFBP7分别是对这些终点的重要预测因子，这些终点均降低和保留的射血率测试，显示了所有三个风险预测模型，在添加了IGFBP7（p <0.001）。在BioStat-CHF验证中，对涉及的调节的不同途径进行了激活。队列。
IGFBP7作为HF患者的独立且可靠的预后生物标志物，均具有降低和保留的射血分数。系统调节，将心力衰竭与感应途径联系起来。
Insulin like growth factor binding protein 7 (IGFBP7) is a marker of senescence secretome and a novel biomarker in patients with heart failure (HF). We evaluated the prognostic value of IGFBP7 in patients with heart failure and examined associations to uncover potential new pathophysiological pathways related to increased plasma IGFBP7 concentrations. We have measured plasma IGFBP7 concentrations in 2250 subjects with new‐onset or worsening heart failure (BIOSTAT‐CHF cohort). Higher IGFBP7 plasma concentrations were found in older subjects, those with worse kidney function, history of atrial fibrillation, and diabetes mellitus type 2, and in subjects with higher number of HF hospitalizations. Higher IGFBP7 levels also correlate with the levels of several circulating biomarkers, including higher NT‐proBNP, hsTnT, and urea levels. Cox regression analyses showed that higher plasma IGFBP7 concentrations were strongly associated with increased risk of all three main endpoints (hospitalization, all‐cause mortality, and combined hospitalization and mortality) (HR 1.75, 95% CI 1.25–2.46; HR 1.71, 95% CI 1.39–2.11; and HR 1.44, 95% CI 1.23–1.70, respectively). IGFBP7 remained a significant predictor of these endpoints in patients with both reduced and preserved ejection fraction. Likelihood ratio test showed significant improvement of all three risk prediction models, after adding IGFBP7 (P < 0.001). A biomarker network analysis showed that IGFBP7 levels activate different pathways involved in the regulation of the immune system. Results were externally validated in BIOSTAT‐CHF validation cohort. IGFPB7 presents as an independent and robust prognostic biomarker in patients with HF, with both reduced and preserved ejection fraction. We validate the previously published data showing IGFBP7 has correlations with a number of echocardiographic markers. Lastly, IGFBP7 pathways are involved in different stages of immune system regulation, linking heart failure to senescence pathways.
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影响因子：
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作者：
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影响因子：
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