The cutaneous vascular system in chronic skin inflammation.
The cutaneous vascular system in chronic skin inflammation.
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DOI：
10.1038/jidsymp.2011.5
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发表时间：
2011-12
影响因子：
--
通讯作者：
Detmar, Michael
中科院分区：
文献类型：
--
作者：
Huggenberger, Reto;Detmar, Michael
血液和淋巴管系统在皮肤稳态中起重要作用。血管生成和淋巴管生成-从现有的新血管生长-由于它们在促进癌症扩散中的作用而受到极大的关注。然而，越来越多的证据表明，这两种血管类型在急性和慢性炎症性疾病中也起着重要作用。血管在炎症中改变其表型（血管重塑）。在发炎的皮肤中，血管重塑由具有增加的血流量的高渗透性、扩大的血管网络和炎性细胞的流入组成。在慢性炎症期间，活化的内皮表达粘附分子、细胞因子和导致白细胞滚动、附着和迁移到皮肤中的其他分子。最近的研究表明，抑制血管活化发挥有效的抗炎特性。因此，抗血管生成药物可用于治疗炎症。特别是，局部应用抗血管生成药物可能是理想的适合规避血管生成抑制剂的全身治疗的不良反应。我们最近的研究结果表明，刺激淋巴管的生长和功能出乎意料地代表了一种治疗慢性炎症性疾病的新方法。
The blood and lymphatic vasculature play an important role in skin homeostasis. Angiogenesis and lymphangiogenesis – the growth of new vessels from existing ones - have received tremendous interest because of their role in promoting cancer spread. However, there is increasing evidence that both vessel types also play a major role in acute and chronic inflammatory disorders. Vessels change their phenotype in inflammation (vascular remodeling). In inflamed skin, vascular remodeling consists of a hyperpermeable, enlarged network of vessels with increased blood flow, and influx of inflammatory cells. During chronic inflammation, the activated endothelium expresses adhesion molecules, cytokines, and other molecules that lead to leukocyte rolling, attachment and migration into the skin. Recent studies reveal that inhibition of blood vessel activation exerts potent anti-inflammatory properties. Thus, anti-angiogenic drugs might be used to treat inflammatory conditions. In particular, topical application of anti-angiogenic drugs might be ideally suited to circumvent the adverse effects of systemic therapy with angiogenesis inhibitors. Our recent results indicate that stimulation of lymphatic vessel growth and function unexpectedly represents a novel approach for treating chronic inflammatory disorders.
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影响因子：
6.5
作者：
BROWN, LF;HARRIST, TJ;DETMAR, M
通讯作者：
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作者：
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