DNA damage accumulation in aging brain and its links to Alzheimer’s disease progression
DNA damage accumulation in aging brain and its links to Alzheimer’s disease progression
复制标题
衰老大脑中 DNA 损伤的积累及其与阿尔茨海默病进展的关系
DOI：
10.1007/s42764-022-00069-y
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Xu Li
中科院分区：
文献类型：
--
作者：
Han Zhao;Shiyao Wang;Xu Li
DNA携带着构建整个人体的信息，不断受到各种内源性和环境因素的挑战，最终导致突变和基因组不稳定，引发广泛的细胞反应，引发多种人类疾病。细胞已经进化出多种DNA修复机制来应对DNA损伤。最近的研究发现，大脑中的DNA损伤与许多神经系统疾病有关。在这篇综述中，我们讨论了大脑中的DNA损伤如何与阿尔茨海默病相关，以及修复机制的缺乏如何加速与年龄相关的阿尔茨海默病的进展。我们还审查了DNA损伤的潜在来源，这可能与阿尔茨海默病的认知能力下降密切相关。
DNA, which carries information to build the entire human body, is constantly challenged by a variety of endogenous and environmental agents, ultimately leading to mutations and genomic instability, triggering a wide range of cellular responses and causing diverse human diseases. Cells have evolved a variety of DNA repair mechanisms to respond to DNA damage. Recent findings have linked DNA damage in the brain with many neurological diseases. In this review, we discuss how DNA damage in the brain correlates with Alzheimer’s disease and how the absence of repair mechanisms accelerates age-related Alzheimer’s disease progression. We also review the potential sources of DNA damage, which may be closely associated with cognitive decline in Alzheimer’s disease.
影响因子：
4.5
作者：
Hart, BA;Potts, RJ;Watkin, RD
通讯作者：
Watkin, RD
影响因子：
7.2
作者：
West AE;Greenberg ME
通讯作者：
Greenberg ME
影响因子：
3.7
作者：
GREENWOOD, JA;JOHNSON, GVW
通讯作者：
JOHNSON, GVW