The Relationship between H. pylori Infection and Osteoporosis in Japan.
The Relationship between H. pylori Infection and Osteoporosis in Japan.
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DOI：
10.1155/2014/340765
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发表时间：
2014
影响因子：
2
通讯作者：
Watanabe S
中科院分区：
文献类型：
--
作者：
Asaoka D;Nagahara A;Hojo M;Sasaki H;Shimada Y;Yoshizawa T;Osada T;Watanabe S
背景和目的。H.幽门螺杆菌感染引起胃粘膜慢性炎症。然而，这种局部炎症可能导致消化道外疾病。我们的目的是研究H.幽门螺杆菌感染和骨质疏松症。方法.这项横断面研究是在顺天堂大学医院2008年至2014年的门诊患者中进行的。患者资料的参与者，H。pylori感染状况、合并症、内科治疗、腰椎双能X线吸收测定法（DXA）和骨转换指标，并进行上消化道内镜检查以检查反流性食管炎、食管裂孔疝、消化性溃疡病（PUD）和内镜胃粘膜萎缩（EGA）。骨质疏松症的诊断按照日本标准进行。我们调查了骨质疏松症的危险因素。结果在合格的200例研究受试者中，41例为骨质疏松症。双因素分析显示，年龄、性别、BMI、饮酒、吸烟、H。pylori、骨特异性ALP、PUD和EGA与骨质疏松症有关。多因素分析显示年龄（OR 1.13; 95%CI 1.07-1.20）、女性（OR 4.77; 95%CI 1.78-12.77）、BMI（OR 0.79; 95%CI 0.68-0.92）、H. pylori（OR 5.33; 95%CI 1.73-16.42）和PUD（OR 4.98; 95%CI 1.51-16.45）与骨质疏松症有关。结论. H.幽门螺杆菌感染可能是日本骨质疏松症的危险因素。
Background and Objective. H. pylori infection causes a chronic inflammation in the gastric mucosa. However, this local inflammation may result in extra-digestive conditions. Our aim is to investigate the relationship between H. pylori infection and osteoporosis in Japan. Methods. This cross-sectional study was conducted among outpatients at the Juntendo University Hospital between 2008 and 2014. Participants for patient profile, H. pylori infection status, comorbidity, internal medical therapies, lumbar dual-energy X-ray absorptiometry (DXA), and bone turnover marker were collected and upper gastrointestinal endoscopy for reflux esophagitis, hiatal hernia, peptic ulcer disease (PUD), and endoscopic gastric mucosal atrophy (EGA) was performed. The diagnosis of osteoporosis was performed in accordance with the Japanese criteria. We investigated risk factors of osteoporosis. Results. Of the eligible 200 study subjects, 41 cases were of osteoporosis. Bivariate analysis showed that age, being female, BMI, alcohol, smoking, H. pylori, bone-specific ALP, PUD, and EGA were related to osteoporosis. Multivariate analysis showed that age (OR 1.13; 95%CI 1.07–1.20), being female (OR 4.77; 95%CI 1.78–12.77), BMI (OR 0.79; 95%CI 0.68–0.92), H. pylori (OR 5.33; 95%CI 1.73–16.42), and PUD (OR 4.98; 95%CI 1.51–16.45) were related to osteoporosis. Conclusions. H. pylori infection may be a risk factor of osteoporosis in Japan.
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影响因子：
20.3
作者：
Riggs, BL;Khosla, S;Melton, LJ
通讯作者：
Melton, LJ
影响因子：
3.7
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CRABTREE, JE;PEICHL, P;LINDLEY, IJD
通讯作者：
LINDLEY, IJD
影响因子：
4
作者：
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通讯作者：
Tenenhouse, A
影响因子：
6.4
作者：
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通讯作者：
Hatakeyama, M
影响因子：
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作者：
Kakehasi, Adriana M.;Mendes, Cláudia M. C.;Barbosa, Alfredo J. A.
通讯作者：
Barbosa, Alfredo J. A.