Plasma membrane growth during the cell cycle: unsolved mysteries and recent progress.
Plasma membrane growth during the cell cycle: unsolved mysteries and recent progress.
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DOI：
10.1016/j.ceb.2012.10.008
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发表时间：
2012-12
影响因子：
7.5
通讯作者：
Kellogg, Douglas R.
中科院分区：
文献类型：
--
作者：
McCusker, Derek;Kellogg, Douglas R.
质膜的生长与DNA复制、染色体分离和核糖体生物发生一样是细胞繁殖的基础，但对其潜在机制知之甚少。在细胞周期中，膜的生长需要控制膜生长的起始、位置和程度的机制，以及协调膜生长与细胞周期进程的机制。最近的实验已经建立了膜生长和核心细胞周期调节因子之间的联系。对这些联系的进一步分析将有助于深入了解细胞生长的保守和基本机制。更好地了解膜生长发生的后高尔基途径将对未来的进展至关重要。
Growth of the plasma membrane is as fundamental to cell reproduction as DNA replication, chromosome segregation and ribosome biogenesis, yet little is known about the underlying mechanisms. Membrane growth during the cell cycle requires mechanisms that control the initiation, location, and extent of membrane growth, as well as mechanisms that coordinate membrane growth with cell cycle progression. Recent experiments have established links between membrane growth and core cell cycle regulators. Further analysis of these links will yield insights into conserved and fundamental mechanisms of cell growth. A better understanding of the post-Golgi pathways by which membrane growth occurs will be essential for future progress.
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