Association between myocardial extracellular volume and strain analysis through cardiovascular magnetic resonance with histological myocardial fibrosis in patients awaiting heart transplantation.
Association between myocardial extracellular volume and strain analysis through cardiovascular magnetic resonance with histological myocardial fibrosis in patients awaiting heart transplantation.
复制标题
DOI：
10.1186/s12968-018-0445-z
复制
发表时间：
2018-04-23
期刊：
影响因子：
--
通讯作者：
Han P
中科院分区：
文献类型：
--
作者：
Cui Y;Cao Y;Song J;Dong N;Kong X;Wang J;Yuan Y;Zhu X;Yan X;Greiser A;Shi H;Han P
心血管磁共振（CMR）衍生的细胞外容积（ECV）和组织跟踪应变分析被提议作为量化心肌纤维化和变形的非侵入性方法。本研究旨在（1）从组织学上验证心肌ECV与从接受心脏移植的患者的组织样本中测量的胶原体积分数（CVF）的关系，以及（2）检测接受心脏移植的患者的心肌收缩应变与心肌ECV和组织学CVF之间的相关性。对12例扩张型心肌病（DCM）和10例缺血性心肌病（ICM）患者进行了改良Look反转恢复（MOLLI）序列T1标测、T2标测和ECV。采用CMR电影图像和组织追踪分析软件定量测量心肌收缩期应变，包括左室整体纵向应变（GLS）、周向应变（GCS）和径向应变（GRS）。从心脏的16个节段中的每一个节段收集组织样品，并用苦味酸天狼星红染色以进行组织学CVF定量。基于每例患者的分析，在DCM和ICM患者中观察到整体心肌ECV和组织学CVF之间的强相关性（分别为r = 0.904和r = 0.901，p < 0.001）。在线性混合效应回归分析中，DCM和ICM患者的ECV与组织学CVF在每个节段基础上具有良好的相关性（分别为β = 0.838和β = 0.915，p < 0.001）。在多元线性回归分析中，组织学CVF是等待心脏移植患者ECV的最强独立决定因素（标准化β = 0.860，p < 0.001）。而等待心脏移植患者的T2时间、GLS、GCS和GRS与ECV和CVF无显著相关性。CMR的ECV与组织学CVF相关性良好，表明其作为心肌纤维化定量的无创工具的潜力。此外，在等待心脏移植的患者中，受损的心肌收缩应变与ECV和CVF无关。
Cardiovascular magnetic resonance (CMR)-derived extracellular volume (ECV) and tissue tracking strain analyses are proposed as non-invasive methods for quantifying myocardial fibrosis and deformation. This study sought (1) to histologically validate myocardial ECV against the collagen volume fraction (CVF) measured from tissue samples of patients undergoing heart transplantation and (2) to detect the correlations between myocardial systolic strain and the myocardial ECV and histological CVF in patients undergoing heart transplantation. A total of 12 dilated cardiomyopathy (DCM) and 10 ischaemic cardiomyopathy (ICM) patients underwent T1 mapping with the Modified Look Locker Inversion recovery (MOLLI) sequence, T2 mapping and ECV. Myocardial systolic strain, including left ventricular global longitudinal (GLS), circumferential (GCS) and radial strain (GRS), were quantified using CMR cine images with tissue tracking analysis software. Tissue samples were collected from each of 16 segments of the explanted hearts and were stained with picrosirius red for histological CVF quantification. A strong relationship was observed between the global myocardial ECV and histological CVF in the DCM and ICM patients based on a per-patient analysis (r = 0.904 and r = 0.901, respectively, p < 0.001). In the linear mixed-effects regression analysis, ECV correlated well with the histological CVF in the DCM and ICM patients on a per-segment basis (β = 0.838 and β = 0.915, respectively, p < 0.001). In the multivariate linear regression analysis, histological CVF was the strongest independent determinant of ECV in the patients awaiting heart transplantation (standardised β = 0.860, p < 0.001). However, the T2 time, GLS, GCS and GRS showed no significant associations with ECV and CVF in the patients awaiting heart transplantation. ECV derived from CMR correlated well with histological CVF, indicating its potential as a non-invasive tool for the quantification of myocardial fibrosis. Additionally, impaired myocardial systolic strains were not associated with the ECV and CVF in the patients awaiting heart transplantation.
登录
查看更多内容
影响因子：
24
作者：
Fihn, Stephan D.;Gardin, Julius M.;Yancy, Clyde W.
通讯作者：
Yancy, Clyde W.
影响因子：
7.5
作者：
Miller, Christopher A.;Naish, Josephine H.;Schmitt, Matthias
通讯作者：
Schmitt, Matthias
影响因子：
37.8
作者：
Cheong, Benjamin Y. C.;Muthupillai, Raja;Flamm, Scott D.
通讯作者：
Flamm, Scott D.
T1 映射测量心肌纤维化的组织学验证：系统评价和荟萃分析
DOI：
10.1186/s12968-016-0313-7
发表时间：
2016-12-12
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Diao KY;Yang ZG;Xu HY;Liu X;Zhang Q;Shi K;Jiang L;Xie LJ;Wen LY;Guo YK
通讯作者：
Guo YK
影响因子：
37.8
作者：
Izawa, H;Murohara, T;Yokota, M
通讯作者：
Yokota, M