Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis.
Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis.
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T1 映射测量心肌纤维化的组织学验证：系统评价和荟萃分析
DOI：
10.1186/s12968-016-0313-7
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发表时间：
2016-12-12
期刊：
影响因子：
--
通讯作者：
Guo YK
中科院分区：
文献类型：
--
作者：
Diao KY;Yang ZG;Xu HY;Liu X;Zhang Q;Shi K;Jiang L;Xie LJ;Wen LY;Guo YK
背景心肌纤维化是多种疾病共同的终末途径，这一点越来越受到人们的重视。因此，开发一种准确、简便的方法来评价心肌纤维化是非常重要的。虽然T1标测是心肌活检的潜在替代方法，但验证研究仅限于少量，技术方面各不相同，仅包括有限数量的疾病。进行了系统的回顾和荟萃分析，客观和全面地评价性能的T1映射对心肌纤维化的定量使用心血管磁共振（CMR）。MethodsPubMed，EMBASE和科克伦图书馆数据库进行了搜索的研究应用T1映射来衡量心肌纤维化，并通过组织学分析验证的结果。结果共纳入15篇文献，包括308例有CMR和心肌活检的患者，T1标测ECV与心肌活检的合并相关系数为0.884（95%CI：0.854，0.914），无显著异质性（卡方检验= 7.44; Q检验P =0.489，I^2 = 0.00%）。结论通过T1标测定量测量心肌纤维化与心肌活检测量结果具有良好的总体相关性。需要进一步的研究来确定不同心肌病活检结果的T1标测结果的校准。
BackgroundMyocardial fibrosis is being increasingly recognised as a common final pathway of a wide range of diseases. Thus, the development of an accurate and convenient method to evaluate myocardial fibrosis is of major importance. Although T1 mapping is a potential alternative for myocardial biopsy, validation studies are limited to small numbers and vary regarding technical facets, and include only a restricted number of disease. A systematic review and meta-analysis was conducted to objectively and comprehensively evaluate the performance of T1 mapping on the quantification of myocardial fibrosis using cardiovascular magnetic resonance (CMR).MethodsPubMed, EMBASE and the Cochrane Library databases were searched for studies applying T1 mapping to measure myocardial fibrosis and that validated the results via histological analysis. A pooled correlation coefficient between the CMR and histology measurements was used to evaluate the performance of the T1 mapping.ResultsA total of 15 studies, including 308 patients who had CMR and myocardial biopsy were included and the pooled correlation coefficient between ECV measured by T1 mapping and biopsy for the selected studies was 0.884 (95% CI: 0.854, 0.914) and was not notably heterogeneous chi-squared = 7.44;P =0.489 for the Q test and I^2 = 0.00%).ConclusionsThe quantitative measurement of myocardial fibrosis via T1 mapping is associated with a favourable overall correlation with the myocardial biopsy measurements. Further studies are required to determine the calibration of the T1 mapping results for the biopsy findings of different cardiomyopathies.
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影响因子：
7.5
作者：
Miller, Christopher A.;Naish, Josephine H.;Schmitt, Matthias
通讯作者：
Schmitt, Matthias
影响因子：
7.5
作者：
Mascherbauer, Julia;Marzluf, Beatrice A.;Bonderman, Diana
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Bonderman, Diana
影响因子：
24
作者：
Mewton, Nathan;Liu, Chia Ying;Croisille, Pierre;Bluemke, David;Lima, Joao A. C.
通讯作者：
Lima, Joao A. C.
影响因子：
6.2
作者：
Iles, Leah M.;Ellims, Andris H.;Taylor, Andrew J.
通讯作者：
Taylor, Andrew J.
DOI：
10.1186/1532-429x-13-75
发表时间：
2011-11-28
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Lee JJ;Liu S;Nacif MS;Ugander M;Han J;Kawel N;Sibley CT;Kellman P;Arai AE;Bluemke DA
通讯作者：
Bluemke DA