Second‐trimester pregnancy loss is associated with activated protein C resistance
Second‐trimester pregnancy loss is associated with activated protein C resistance
复制标题
妊娠中期流产与激活的蛋白 C 抵抗有关
DOI：
10.1046/j.1365-2141.0000.d01-1465.x
复制
发表时间：
1996
影响因子：
6.5
通讯作者：
H. Cohen
中科院分区：
文献类型：
--
作者：
R. Rai;L. Regan;E. Hadley;M. Dave;H. Cohen
我们研究了活化蛋白C抵抗（APCR）是否与妊娠中期流产有关。有中期妊娠流产史的女性中APCR的患病率（10/50; 20%）显著高于仅有早期妊娠流产史的女性（4/70; 5.7%）或无既往流产史的经产女性对照组（3/70; 4.3%）（P <0.02）。 这些结果表明，APCR可能是中期妊娠丢失的重要机制，可能与妊娠期间发生的血管内凝血增加有关。
We have investigated whether activated protein C resistance (APCR) is associated with second‐trimester miscarriage. The prevalence of APCR was significantly higher amongst women with a history of second‐trimester miscarriage (10/50; 20%) compared with either women with a history of first‐trimester miscarriages only (4/70; 5.7%) or a control group of parous women with no previous history of pregnancy losses (3/70; 4.3%) (P < 0.02). These results suggest that APCR may be an important mechanism of second‐trimester pregnancy loss, possibly related to the increase in intravascular coagulation that occurs during pregnancy.
影响因子：
20.3
作者：
P. Comp;G. R. Thurnau;J. Welsh;C. T. Esmon
通讯作者：
P. Comp;G. R. Thurnau;J. Welsh;C. T. Esmon