Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia.
Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia.
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DOI：
10.1371/journal.pone.0244320
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Borsook D
中科院分区：
文献类型：
--
作者：
Maleki N;Szabo E;Becerra L;Moulton E;Scrivani SJ;Burstein R;Borsook D
在一些患者中，偏头痛发作与异常性疼痛的症状相关，其可以是局部的（头部的）或全身的（头部外的）。使用功能性神经成像和皮肤热刺激，我们的目的是研究发作性偏头痛患者（n = 19）的脑激活的差异，根据他们的异常性疼痛状态定义的发作和发作间期疼痛耐受阈值之间的变化，每个主题在成像时。在这项前瞻性成像研究中，在脑干/脑桥、丘脑、小脑、扣带皮层中发现发作期和发作间期访视的脑活动存在差异。在丘脑和三叉神经核中，沿着三叉神经通路对伤害性热刺激的激活模式在无异常性疼痛与全身性异常性疼痛中也观察到显着差异，但三叉神经节中没有激活差异。功能性磁共振成像（fMRI）的结果提供了直接的证据，认为偏头痛患者在发作期异常性疼痛，三叉神经脊束核和后丘脑变得高度反应（致敏）-在一定程度上，他们介导头部和脑外异常性疼痛，分别。此外，在全身性异常性疼痛中，下行镇痛系统似乎被“关闭”。
In some patients, migraine attacks are associated with symptoms of allodynia which can be localized (cephalic) or generalized (extracephalic). Using functional neuroimaging and cutaneous thermal stimulation, we aimed to investigate the differences in brain activation of patients with episodic migraine (n = 19) based on their allodynic status defined by changes between ictal and interictal pain tolerance threshold for each subject at the time of imaging. In this prospective imaging study, differences were found in brain activity between the ictal and interictal visits in the brainstem/pons, thalamus, insula, cerebellum and cingulate cortex. Significant differences were also observed in the pattern of activation along the trigeminal pathway to noxious heat stimuli in no allodynia vs. generalized allodynia in the thalamus and the trigeminal nucleus but there were no activation differences in the trigeminal ganglion. The functional magnetic resonance imaging (fMRI) findings provide direct evidence for the view that in migraine patients who are allodynic during the ictal phase of their attacks, the spinal trigeminal nucleus and posterior thalamus become hyper-responsive (sensitized)–to the extent that they mediate cephalic and extracephalic allodynia, respectively. In addition, descending analgesic systems seem as “switched off” in generalized allodynia.
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DOI：
10.1186/s10194-018-0927-2
发表时间：
2018-11-08
期刊：
The journal of headache and pain
影响因子：
--
作者：
Christensen CE;Younis S;Deen M;Khan S;Ghanizada H;Ashina M
通讯作者：
Ashina M
影响因子：
3.7
作者：
Johansen-Berg, H;Behrens, TEJ;Matthews, PM
通讯作者：
Matthews, PM
影响因子：
5.7
作者：
Jahn A;Nee DE;Alexander WH;Brown JW
通讯作者：
Brown JW
影响因子：
11.2
作者：
Burstein, R;Collins, B;Jakubowski, M
通讯作者：
Jakubowski, M
影响因子：
3.7
作者：
Kunz, Miriam;Peter, Jessica;Lautenbacher, Stefan
通讯作者：
Lautenbacher, Stefan