SpliceSeq: a resource for analysis and visualization of RNA-Seq data on alternative splicing and its functional impacts.
SpliceSeq: a resource for analysis and visualization of RNA-Seq data on alternative splicing and its functional impacts.
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DOI：
10.1093/bioinformatics/bts452
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发表时间：
2012-09-15
期刊：
影响因子：
--
通讯作者：
Weinstein JN
中科院分区：
文献类型：
--
作者：
Ryan MC;Cleland J;Kim R;Wong WC;Weinstein JN
SpliceSeq是一个RNA-Seq数据资源，它提供了一个清晰的选择性剪接视图，并识别由剪接变化引起的潜在功能变化。它显示直观的可视化和优先排序的结果列表，突出拼接事件及其生物学后果。SpliceSeq明确地将reads与基因剪接图进行比对，促进了对其他格式无法充分表示的大型复杂转录变体的准确分析。可用性和实现：SpliceSeq可在http://bioinformatics.mdanderson.org/main/SpliceSeq:Overview免费获得。该应用程序是一个Java程序，可以通过浏览器启动或在本地安装。本地安装需要MySQL和Bowtie。补充信息：补充数据可在Bioinformatics在线获取。
Summary: SpliceSeq is a resource for RNA-Seq data that provides a clear view of alternative splicing and identifies potential functional changes that result from splice variation. It displays intuitive visualizations and prioritized lists of results that highlight splicing events and their biological consequences. SpliceSeq unambiguously aligns reads to gene splice graphs, facilitating accurate analysis of large, complex transcript variants that cannot be adequately represented in other formats. Availability and implementation: SpliceSeq is freely available at http://bioinformatics.mdanderson.org/main/SpliceSeq:Overview. The application is a Java program that can be launched via a browser or installed locally. Local installation requires MySQL and Bowtie. Contact: mryan@insilico.us.com Supplementary Information: Supplementary data are available at Bioinformatics online.
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作者：
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通讯作者：
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